trifluoro-methanesulfonic acid 7-methoxy-3-(4-methoxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-5-yl ester

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Chemical Name:trifluoro-methanesulfonic acid 7-methoxy-3-(4-methoxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-5-yl ester
CAS No.:887468-56-6
Molecular Formula:C₁₇H₁₃F₃N₂O₆S
Molecular Weight:430.361
Hs Code.:

Synonyms:trifluoro-methanesulfonic acid 7-methoxy-3-(4-methoxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-5-yl ester

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Chemical Property of trifluoro-methanesulfonic acid 7-methoxy-3-(4-methoxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-5-yl ester

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Technology Process of trifluoro-methanesulfonic acid 7-methoxy-3-(4-methoxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-5-yl ester

There total 8 articles about trifluoro-methanesulfonic acid 7-methoxy-3-(4-methoxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-5-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 628687-05-8
5-hydroxy-7-methoxy-3-(4-methoxyphenyl)-4(3H)-quinazolinone

: 37595-74-7
N,N-phenylbistrifluoromethane-sulfonimide

: 887468-56-6
trifluoro-methanesulfonic acid 7-methoxy-3-(4-methoxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-5-yl ester

Guidance literature:: 5-hydroxy-7-methoxy-3-(4-methoxyphenyl)-4(3H)-quinazolinone; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;

N,N-phenylbistrifluoromethane-sulfonimide; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1h;
DOI:10.1021/jm0509389

Reference yield:

: 21577-57-1
2-amino-4,6-dimethoxybenzoic acid

: 887468-56-6
trifluoro-methanesulfonic acid 7-methoxy-3-(4-methoxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-5-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 92 percent / tetrahydrofuran / 0 - 20 °C

2.1: 59 percent / DMAP / N,N-dimethyl-acetamide / 24 h / 110 °C

3.1: 55.1 g / 4 h / Heating

4.1: 48 percent / LiCl / dimethylformamide / 2.5 h / 135 °C

5.1: NaH / dimethylformamide / 1 h / 0 - 20 °C

5.2: 85 percent / dimethylformamide / 1 h / 0 - 20 °C

With dmap; sodium hydride; lithium chloride; In tetrahydrofuran; N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm0509389

Reference yield:

: 63920-75-2
1,2-dihydro-5,7-dimethoxy-3,1-benzoxazine-2,4-dione

: 887468-56-6
trifluoro-methanesulfonic acid 7-methoxy-3-(4-methoxy-phenyl)-4-oxo-3,4-dihydro-quinazolin-5-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 59 percent / DMAP / N,N-dimethyl-acetamide / 24 h / 110 °C

2.1: 55.1 g / 4 h / Heating

3.1: 48 percent / LiCl / dimethylformamide / 2.5 h / 135 °C

4.1: NaH / dimethylformamide / 1 h / 0 - 20 °C

4.2: 85 percent / dimethylformamide / 1 h / 0 - 20 °C

With dmap; sodium hydride; lithium chloride; In N,N-dimethyl acetamide; N,N-dimethyl-formamide;
DOI:10.1021/jm0509389