5-Methyl-2-methylthio-7-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin-4(3H)-on

Base Information

• Chemical Name: 5-Methyl-2-methylthio-7-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin-4(3H)-on
• CAS No.: 75124-29-7
• Molecular Formula: C₃₄H₃₅N₃O₅S
• Molecular Weight: 597.735
• Mol file: 75124-29-7.mol

Synonyms:5-Methyl-2-methylthio-7-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin-4(3H)-on

Chemical Property of 5-Methyl-2-methylthio-7-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin-4(3H)-on

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Methyl-2-methylthio-7-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin-4(3H)-on

There total 3 articles about 5-Methyl-2-methylthio-7-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin-4(3H)-on which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4-Methoxy-5-methyl-2-methylthio-7-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin (64609-35-4) → 5-Methyl-2-methylthio-7-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin-4(3H)-on (75124-29-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; for 15h; Heating;

Reference yield:

2,3,5-tri-O-benzyl-D-ribofuranosyl bromide (57378-89-9) → 5-Methyl-2-methylthio-7-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin-4(3H)-on (75124-29-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) benzyltriethylammonium chloride, aq. NaOH (50percent) / 1) 1,2-dimethoxyethane, room temp., 10 min, 2) benzene, room temp., 3 h

2: 85 percent / 0.5 N HCl / dioxane / 15 h / Heating

With hydrogenchloride; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; In 1,4-dioxane;

Reference yield:

2,3,5-tri-O-benzyl-1-O-(p-nitrobenzoyl)-α,β-D-ribofuranose (75172-84-8) → 5-Methyl-2-methylthio-7-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin-4(3H)-on (75124-29-7)

Guidance literature:

Multi-step reaction with 3 steps

1: HBr(gas.) / CH₂Cl₂

2: 1) benzyltriethylammonium chloride, aq. NaOH (50percent) / 1) 1,2-dimethoxyethane, room temp., 10 min, 2) benzene, room temp., 3 h

3: 85 percent / 0.5 N HCl / dioxane / 15 h / Heating

With hydrogenchloride; sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride; hydrogen bromide; In 1,4-dioxane; dichloromethane;

upstream raw materials:

4-Methoxy-5-methyl-2-methylthio-7-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin

2,3,5-tri-O-benzyl-D-ribofuranosyl bromide

2,3,5-tri-O-benzyl-1-O-(p-nitrobenzoyl)-α,β-D-ribofuranose