57378-89-9

Upstream product

• 51450-29-4 2,3,5-tri-O-benzyl-1-O-(p-nitrobenzoyl)-β-D-ribofuranose 
• 91110-24-6 Acetic acid (2S,3R,4R,5R)-3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl ester 
• 16838-89-4 2,3,5-tri-O-benzyl-D-ribofuranose 

Downstream Products

• 79063-57-3 3-((3S,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-6-nitro-1H-indole 
• 14365-88-9 3-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-purin-6-ylamine 
• 412909-27-4 9-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-9H-purin-6-ylamine 
• 76567-69-6 4-Methoxy-2-methylthio-7-(2,3,5-tri-O-benzyl-β-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin 
• 76567-68-5 4-Methoxy-2-methylthio-7-(2,3,5-tri-O-benzyl-α-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin 
• 64609-35-4 4-Methoxy-5-methyl-2-methylthio-7-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin 
• 64609-34-3 4-Methoxy-5-methyl-2-methylthio-7-(2',3',5'-tri-O-benzyl-β-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin 
• 99512-54-6 4-((2R,3R,4R,5R)-3,4-Bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-4-oxo-butyric acid methyl ester 
• 58-61-7 adenosine 
• 158227-80-6 7-((2S,3S,4R,5R)-3,4-bis(benzyloxy)-5-((benzyloxy)methyl)-tetrahydrofuran-2-yl)pyrrolo[2,1-f][1,2,4]triazin-4-amine 
• 1191237-69-0 (2R,3R,4S,5R)?2?(4?aminopyrrolo[1,2?f][1,2,4]triazin?7?yl)?3,4?dihydroxy?5?(hydroxymethyl)tetrahydrofuran?2?carbonitrile 
• 66281-87-6 5-Methyl-2-methylthio-7-(2',3',5'-tri-O-benzyl-β-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin-4(3H)-on 
• 75124-29-7 5-Methyl-2-methylthio-7-(2',3',5'-tri-O-benzyl-α-D-ribofuranosyl)pyrrolo<2,3-d>pyrimidin-4(3H)-on 

Relevant academic research and scientific papers

Chemical investigations in the synthesis of O-serinyl aminoribosides

Glycosylation involving d-ribose derivatives and various N-protected tert-butyl l-serinates can be achieved efficiently by careful choice of the activation method at the anomeric position and of the Lewis acid promoter. The conditions described allow the major formation of the β-anomer required for further elaboration to liposidomycin and caprazamycin analogues.

A versatile scaffold for a library of liposidomycins analogues: A crucial and potent glycosylation step

A key step for the synthesis of a diazepanone scaffold dedicated to a library of MraY inhibitors is described. It involves the O-glycosylation of a conveniently protected L-serine by a D-ribofuranose derivative. High yield and selectivity were obtained.

Synthesis of C-Nucleosides via Radical Coupling Reaction

Photolysis of O-acyl derivatives of N-hydroxy-2-thiopyridone, prepared from tetrahydrofuran-2-carboxylic acid, D-ribofuranosylmethanoic acid, and D-ribopyranosylmethanoic acid, gave the corresponding C-nucleoside derivatives in the presence of heteroaromatic compounds via radical pathways.The essential step in this method is a radical coupling reaction of D-ribofuranosyl radical or D-ribopyranosyl radical and some heteroaromatic bases.This is a new method for the preparation of C-nucleosides using sugar carboxylic acids.