(3S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-2,5-bis-methoxymethoxy-3-methyl-phenyl)-3,5-dimethyl-hexan-2-ol

Base Information

Chemical Name:(3S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-2,5-bis-methoxymethoxy-3-methyl-phenyl)-3,5-dimethyl-hexan-2-ol
CAS No.:638188-67-7
Molecular Formula:C₃₆H₅₂O₇Si
Molecular Weight:624.89
Hs Code.:

Synonyms:(3S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-2,5-bis-methoxymethoxy-3-methyl-phenyl)-3,5-dimethyl-hexan-2-ol

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Chemical Property of (3S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-2,5-bis-methoxymethoxy-3-methyl-phenyl)-3,5-dimethyl-hexan-2-ol

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Technology Process of (3S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-2,5-bis-methoxymethoxy-3-methyl-phenyl)-3,5-dimethyl-hexan-2-ol

There total 9 articles about (3S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-2,5-bis-methoxymethoxy-3-methyl-phenyl)-3,5-dimethyl-hexan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1760-80-1
2-methoxy-3-methylbenzene-1,4-diol

: 638188-67-7
(3S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-2,5-bis-methoxymethoxy-3-methyl-phenyl)-3,5-dimethyl-hexan-2-ol

Guidance literature:: Multi-step reaction with 4 steps

1: NaH / dimethylformamide / 0.5 h / 0 °C

2: N-bromosuccinimide / CHCl₃ / 48 h / 5 °C

3: Mg / tetrahydrofuran / 2 h / Heating

4: 96 percent / CuI / 0.5 h / -30 °C

With N-Bromosuccinimide; copper(l) iodide; sodium hydride; magnesium; In tetrahydrofuran; chloroform; N,N-dimethyl-formamide;
DOI:10.1021/ol035846x

Reference yield:

: 91751-24-5,92817-88-4,123284-89-9,112897-04-8
(R)-3-[(tert-butyldiphenylsilyl)oxy]-2-methylpropanal

: 638188-67-7
(3S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-2,5-bis-methoxymethoxy-3-methyl-phenyl)-3,5-dimethyl-hexan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1.1: n-BuLi / H₂O; tetrahydrofuran

2.1: lithium tri-sec-butylborohydride / 2 h / -90 - -60 °C

2.2: hexamethylphosphoric triamide / 12 h / -78 °C

3.1: i-Bu₂AlH / 2 h / -78 °C

4.1: n-BuLi / 0 °C

5.1: m-chloroperbenzoic acid / CH₂Cl₂ / 20 °C

6.1: 96 percent / CuI / 0.5 h / -30 °C

With copper(l) iodide; n-butyllithium; L-Selectride; diisobutylaluminium hydride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; water; 1.1: Horner-Wadsworth-Emmons olefination;
DOI:10.1021/ol035846x

Reference yield:

: 320742-72-1
(2S,4S)-2,4-dimethyl-1-(tert-butyldiphenylsilyloxy)-5-hexene

: 638188-67-7
(3S,5S)-6-(tert-Butyl-diphenyl-silanyloxy)-1-(4-methoxy-2,5-bis-methoxymethoxy-3-methyl-phenyl)-3,5-dimethyl-hexan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: m-chloroperbenzoic acid / CH₂Cl₂ / 20 °C

2: 96 percent / CuI / 0.5 h / -30 °C

With copper(l) iodide; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;
DOI:10.1021/ol035846x