2-fluoro-5-[5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzonitrile

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Chemical Name:2-fluoro-5-[5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzonitrile
CAS No.:503614-66-2
Molecular Formula:C₂₄H₁₃F₅N₄O₂
Molecular Weight:484.385
Hs Code.:

Synonyms:2-fluoro-5-[5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzonitrile

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Chemical Property of 2-fluoro-5-[5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzonitrile

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Technology Process of 2-fluoro-5-[5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzonitrile

There total 8 articles about 2-fluoro-5-[5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 209960-58-7
1-(3-cyano-4-fluorophenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxylic Acid

: 503614-66-2
2-fluoro-5-[5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / diethyl ether / 1.5 h / 23 °C

2.1: n-butyllithium; diisopropylamine / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / 0.33 h / -78 °C

2.2: 1 h / -78 - 23 °C

3.1: water; sulfuric acid / methanol / 24 h / Reflux

With n-butyllithium; sulfuric acid; water; triethylamine; diisopropylamine; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; diethyl ether;

Reference yield:

: 39998-81-7
2-fluoro-4-iodotoluene

: 503614-66-2
2-fluoro-5-[5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzonitrile

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / acetone / 5 h / Reflux

2.1: tetrabutylammomium bromide / water; toluene / 14 h / Reflux

3.1: water; sodium hydroxide / ethanol / 2 h / Reflux

4.1: methanol / benzene; hexane / 1.25 h / 0 °C

5.1: potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 14 h / 125 °C / Inert atmosphere

6.1: n-butyllithium; diisopropylamine / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / 0.33 h / -78 °C

6.2: 1 h / -78 - 23 °C

7.1: water; sulfuric acid / methanol / 24 h / Reflux

With methanol; N-Bromosuccinimide; copper(l) iodide; n-butyllithium; 2,2'-azobis(isobutyronitrile); sulfuric acid; tetrabutylammomium bromide; water; potassium carbonate; diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; hexane; water; dimethyl sulfoxide; acetone; toluene; benzene;

Reference yield:

: 345963-95-3
(2-fluoro-4-iodophenyl)-acetonitrile

: 503614-66-2
2-fluoro-5-[5-{[2-fluoro-4-(2-oxo-1(2H)-pyridinyl)phenyl]acetyl}-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; sodium hydroxide / ethanol / 2 h / Reflux

2.1: methanol / benzene; hexane / 1.25 h / 0 °C

3.1: potassium carbonate; copper(l) iodide / dimethyl sulfoxide / 14 h / 125 °C / Inert atmosphere

4.1: n-butyllithium; diisopropylamine / tetrahydrofuran; N,N,N,N,N,N-hexamethylphosphoric triamide / 0.33 h / -78 °C

4.2: 1 h / -78 - 23 °C

5.1: water; sulfuric acid / methanol / 24 h / Reflux

With methanol; copper(l) iodide; n-butyllithium; sulfuric acid; water; potassium carbonate; diisopropylamine; sodium hydroxide; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; ethanol; hexane; dimethyl sulfoxide; benzene;