2-(Benzoylamino)-5-<(2'R)-cis-3'-2',5'-dihydro-4'-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-5'-(hydroxymethyl)-2'-furanyl>pyridine

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Chemical Name:2-(Benzoylamino)-5-<(2'R)-cis-3'-2',5'-dihydro-4'-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-5'-(hydroxymethyl)-2'-furanyl>pyridine
CAS No.:166266-24-6
Molecular Formula:C₃₃H₃₄N₂O₄Si
Molecular Weight:550.729
Hs Code.:

Synonyms:2-(Benzoylamino)-5-<(2'R)-cis-3'-2',5'-dihydro-4'-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-5'-(hydroxymethyl)-2'-furanyl>pyridine

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Chemical Property of 2-(Benzoylamino)-5-<(2'R)-cis-3'-2',5'-dihydro-4'-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-5'-(hydroxymethyl)-2'-furanyl>pyridine

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Technology Process of 2-(Benzoylamino)-5-<(2'R)-cis-3'-2',5'-dihydro-4'-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-5'-(hydroxymethyl)-2'-furanyl>pyridine

There total 3 articles about 2-(Benzoylamino)-5-<(2'R)-cis-3'-2',5'-dihydro-4'-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-5'-(hydroxymethyl)-2'-furanyl>pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 504-29-0
2-aminopyridine

: 166266-24-6
2-(Benzoylamino)-5-<(2'R)-cis-3'-2',5'-dihydro-4'-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-5'-(hydroxymethyl)-2'-furanyl>pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / HIO₄*2H₂O, I₂, H₂SO₄ / aq. acetic acid / 4 h / 80 °C

2: 90 percent / pyridine / 18 h

3: tri-n-butylamine / Pd(dba)2, tris(pentafluorophenyl)phosphine / acetonitrile / 1.) r.t., 20 min, 2.) 80 deg C, 8 h

With pyridine; tributyl-amine; sulfuric acid; iodine; periodic acid; tris(pentafluorophenyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In acetic acid; acetonitrile;
DOI:10.1021/jo00121a071

Reference yield:

: 20511-12-0
2-amino-5-iodopyridine

: 166266-24-6
2-(Benzoylamino)-5-<(2'R)-cis-3'-2',5'-dihydro-4'-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-5'-(hydroxymethyl)-2'-furanyl>pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / pyridine / 18 h

2: tri-n-butylamine / Pd(dba)2, tris(pentafluorophenyl)phosphine / acetonitrile / 1.) r.t., 20 min, 2.) 80 deg C, 8 h

With pyridine; tributyl-amine; tris(pentafluorophenyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In acetonitrile;
DOI:10.1021/jo00121a071

Reference yield:

: 130277-32-6
((2R,3S)-3-(tert-butyldiphenylsilyloxy)-2,3-dihydrofuran-2-yl)methanol

: 166266-23-5
2-(N-Benzoylamino)-5-iodopyridine

: 166266-24-6
2-(Benzoylamino)-5-<(2'R)-cis-3'-2',5'-dihydro-4'-<<(1,1-dimethylethyl)diphenylsilyl>oxy>-5'-(hydroxymethyl)-2'-furanyl>pyridine

Guidance literature:: With tributyl-amine; tris(pentafluorophenyl)phosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In acetonitrile; Yield given; 1.) r.t., 20 min, 2.) 80 deg C, 8 h;
DOI:10.1021/jo00121a071