166266-23-5Relevant academic research and scientific papers
Mapping out the Relative Influence of Hydrogen and Halogen Bonds in Crystal Structures of a Family of Amide-Substituted Pyridines
Abeysekera, Amila M.,Day, Victor W.,Sinha, Abhijeet S.,Aaker?y, Christer B.
, p. 7399 - 7410 (2020/11/03)
The simultaneous use of hydrogen bonds and halogen bonds in crystal engineering strategies has previously been employed in order to generate new solid forms with applications in e.g. pharmaceutical and agrochemical industries. Unfortunately, it is not eas
A facile tandem decyanation/cyanation reaction of α-iminonitriles toward cyano-substituted amides
Chen, Zhengwang,Liang, Pei,Liu, Botao,Luo, Haiqing,Zheng, Jing,Wen, Xiaowei,Liu, Tanggao,Ye, Min
supporting information, p. 8481 - 8485 (2018/11/27)
A new tandem decyanation/cyanation reaction of α-iminonitriles has been developed. A variety of cyano-substituted aryl amides and heteroaryl amides are synthesized in good yields. Both electron-rich and electron-deficient groups are compatible with the standard conditions. This reaction features a nonmetallic cyano source, tandem decyanation and cyanation reaction, waste utilization of the HCN from the hydrolysis of α-iminonitriles, formation of two important functional groups in one-step operation, etc.
Ce(III)-catalyzed highly efficient synthesis of pyridyl benzamides from aminopyridines and nitroolefins without external oxidants
Chen, Zhengwang,Wen, Xiaowei,Qian, Yiping,Liang, Pei,Liu, Botao,Ye, Min
supporting information, p. 1247 - 1251 (2018/03/06)
An efficient synthesis of a variety of pyridyl benzamides from 2-aminopyridines and nitroolefins is described. This rare-earth-metal-catalyzed reaction provides the corresponding products with broad substrate scope in moderate to excellent yields, in the absence of additives and external oxidants. Water is used as the source of the carbonyl oxygen atom in pyridyl benzamides. Furthermore, 2-substituted oxazolo[4,5-b]pyridines are formed in good yields under the standard conditions when 2-aminopyridin-3-ols are used as the substrates.
N-Heterocyclic Carbene-Catalyzed Mannich Reaction for the Synthesis of β-Amino Ketones: N,N-Dimethylformamide as Carbon Source
Alanthadka, Anitha,Devi, E. Sankari,Selvi, A. Tamil,Nagarajan, Subbiah,Sridharan, Vellaisamy,Maheswari, C. Uma
supporting information, p. 2369 - 2374 (2017/07/22)
The efficiency of N,N-dimethylformamide (DMF) in the N-heterocyclic carbene-catalyzed Mannich reaction for the synthesis of β-amino ketones has been demonstrated. This strategy involves oxidative coupling of aryl methyl ketones and 2-aminopyridines in the presence of DMF. The reaction does not require pre-functionalization of the substrates, thus making it a practically applicable approach for the generation of β-amino ketones. The reaction requires the use of tin(II) chloride dihydrate (SnCl2?2 H2O) as Lewis acid in the presence of tert-butyl hydroperoxide (TBHP) as the oxidant. The reaction was tolerant to several aryl methyl ketones, including 2-acetylnaphthalene and acetylthiophene. Various substituted 2-aminopyridines react with acetophenone to give the desired β-amino ketones in good yields. (Figure presented.).
