3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethyl-N-(5-(4-phenoxyphenyl)-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamide

Base Information

Chemical Name:3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethyl-N-(5-(4-phenoxyphenyl)-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamide
CAS No.:1369885-85-7
Molecular Formula:C₂₃H₁₉ClF₃N₃O₂S
Molecular Weight:493.937
Hs Code.:

Synonyms:3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethyl-N-(5-(4-phenoxyphenyl)-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamide

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Chemical Property of 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethyl-N-(5-(4-phenoxyphenyl)-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamide

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Technology Process of 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethyl-N-(5-(4-phenoxyphenyl)-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamide

There total 6 articles about 3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethyl-N-(5-(4-phenoxyphenyl)-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.2%

: 74609-46-4
3-(2-chloro-3,3,3-trifluoroprop-1-en-yl)-2,2-dimethylcyclopropanecarboxylic acid

: 299442-68-5
5-(4-phenoxyphenyl)-1,3,4-thiadiazol-2-amine

: 1369885-85-7
3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethyl-N-(5-(4-phenoxyphenyl)-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.3184/174751911X13230201951890

Reference yield:

: 101-84-8
diphenylether

: 1369885-85-7
3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethyl-N-(5-(4-phenoxyphenyl)-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: carbon disulfide / 50 °C

2: sodium hypobromide / tetrahydrofuran / 3 h / 0 - 5 °C / Reflux

3: trichlorophosphate / 4.5 h / 0 - 5 °C / Reflux

4: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With carbon disulfide; sodium hypobromide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.3184/174751911X13230201951890

Reference yield:

: 93-99-2
benzoic acid phenyl ester

: 1369885-85-7
3-(2-chloro-3,3,3-trifluoroprop-1-en-1-yl)-2,2-dimethyl-N-(5-(4-phenoxyphenyl)-1,3,4-thiadiazol-2-yl)cyclopropanecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrazine hydrate / diethylene glycol / 2.5 h / Reflux

1.2: 4 h / Reflux

2.1: carbon disulfide / 50 °C

3.1: sodium hypobromide / tetrahydrofuran / 3 h / 0 - 5 °C / Reflux

4.1: trichlorophosphate / 4.5 h / 0 - 5 °C / Reflux

5.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

With carbon disulfide; sodium hypobromide; benzotriazol-1-ol; hydrazine hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide; diethylene glycol;
DOI:10.3184/174751911X13230201951890