4-cyclopropyl-2-fluoro-5-(5-isopropyl-1H-tetrazol-1-yl)benzenamine

Base Information

Chemical Name:4-cyclopropyl-2-fluoro-5-(5-isopropyl-1H-tetrazol-1-yl)benzenamine
CAS No.:1356493-73-6
Molecular Formula:C₁₃H₁₆FN₅
Molecular Weight:261.302
Hs Code.:

Synonyms:4-cyclopropyl-2-fluoro-5-(5-isopropyl-1H-tetrazol-1-yl)benzenamine

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Chemical Property of 4-cyclopropyl-2-fluoro-5-(5-isopropyl-1H-tetrazol-1-yl)benzenamine

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Technology Process of 4-cyclopropyl-2-fluoro-5-(5-isopropyl-1H-tetrazol-1-yl)benzenamine

There total 5 articles about 4-cyclopropyl-2-fluoro-5-(5-isopropyl-1H-tetrazol-1-yl)benzenamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1356493-70-3
1-(2-cyclopropyl-4-fluoro-5-nitrophenyl)-5-isopropyl-1H-tetrazole

: 1356493-73-6
4-cyclopropyl-2-fluoro-5-(5-isopropyl-1H-tetrazol-1-yl)benzenamine

Guidance literature:: With hydrogen; acetic acid; palladium 10% on activated carbon; In ethanol; water; under 1551.49 Torr;

Reference yield:

: 1003-98-1
2-bromo-4-fluoroaniline

: 1356493-73-6
4-cyclopropyl-2-fluoro-5-(5-isopropyl-1H-tetrazol-1-yl)benzenamine

Guidance literature:: Multi-step reaction with 5 steps

1.1: sulfuric acid / ethyl acetate / -30 - -20 °C

1.2: 1.08 h / -20 - -15 °C

2.1: tricyclohexylphosphine; caesium carbonate / palladium diacetate / toluene; water / 100 °C / Inert atmosphere

3.1: sodium hydrogencarbonate / dichloromethane / 20 °C

3.2: Cooling with ice

4.1: trifluoromethylsulfonic anhydride; trimethylsilylazide / acetonitrile / -5 °C / Inert atmosphere

5.1: hydrogen; acetic acid / palladium 10% on activated carbon / ethanol; water / 1551.49 Torr

With trifluoromethylsulfonic anhydride; trimethylsilylazide; sulfuric acid; hydrogen; sodium hydrogencarbonate; caesium carbonate; acetic acid; tricyclohexylphosphine; palladium 10% on activated carbon; palladium diacetate; In ethanol; dichloromethane; water; ethyl acetate; toluene; acetonitrile;

Reference yield:

: 346433-97-4
2-bromo-4-fluoro-5-nitrophenylamine

: 1356493-73-6
4-cyclopropyl-2-fluoro-5-(5-isopropyl-1H-tetrazol-1-yl)benzenamine

Guidance literature:: Multi-step reaction with 4 steps

1.1: tricyclohexylphosphine; caesium carbonate / palladium diacetate / toluene; water / 100 °C / Inert atmosphere

2.1: sodium hydrogencarbonate / dichloromethane / 20 °C

2.2: Cooling with ice

3.1: trifluoromethylsulfonic anhydride; trimethylsilylazide / acetonitrile / -5 °C / Inert atmosphere

4.1: hydrogen; acetic acid / palladium 10% on activated carbon / ethanol; water / 1551.49 Torr

With trifluoromethylsulfonic anhydride; trimethylsilylazide; hydrogen; sodium hydrogencarbonate; caesium carbonate; acetic acid; tricyclohexylphosphine; palladium 10% on activated carbon; palladium diacetate; In ethanol; dichloromethane; water; toluene; acetonitrile;