tert-butyl (1-((benzyloxy)(3-(dimethylamino)propyl)amino)-1-oxooctan-2-yl)carbamate

Base Information

• Chemical Name: tert-butyl (1-((benzyloxy)(3-(dimethylamino)propyl)amino)-1-oxooctan-2-yl)carbamate
• CAS No.: 1260652-63-8
• Molecular Formula: C₂₅H₄₃N₃O₄
• Molecular Weight: 449.634

Synonyms:tert-butyl (1-((benzyloxy)(3-(dimethylamino)propyl)amino)-1-oxooctan-2-yl)carbamate

Chemical Property of tert-butyl (1-((benzyloxy)(3-(dimethylamino)propyl)amino)-1-oxooctan-2-yl)carbamate

Chemical Property:

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Technology Process of tert-butyl (1-((benzyloxy)(3-(dimethylamino)propyl)amino)-1-oxooctan-2-yl)carbamate

There total 1 articles about tert-butyl (1-((benzyloxy)(3-(dimethylamino)propyl)amino)-1-oxooctan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

3-(benzyloxyamino)-N,N-dimethylpropan-1-amine dihydrochloride + 2-((tertbutoxycarbonyl)amino)octanoic acid (92211-95-5,92211-96-6,14676-00-7) → tert-butyl (1-((benzyloxy)(3-(dimethylamino)propyl)amino)-1-oxooctan-2-yl)carbamate (1260652-63-8)

Guidance literature:

2-((tertbutoxycarbonyl)amino)octanoic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; at 0 ℃; for 0.75h; Inert atmosphere;

3-(benzyloxyamino)-N,N-dimethylpropan-1-amine dihydrochloride; With triethylamine; In tetrahydrofuran; at 60 ℃; for 60h;

DOI:10.1016/j.bmc.2010.10.031

Reference yield: 99.0%

tert-butyl (1-((benzyloxy)(3-(dimethylamino)propyl)amino)-1-oxooctan-2-yl)carbamate (1260652-63-8) + methyl iodide (74-88-4) → 3-[N-(benzyloxy)-2-(tert-butoxycarbonylamino)octanamido]-N,N,N-trimethylpropan-1-aminium iodide (1260652-80-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;

DOI:10.1016/j.bmc.2010.10.031

Reference yield: 96.0%

tert-butyl (1-((benzyloxy)(3-(dimethylamino)propyl)amino)-1-oxooctan-2-yl)carbamate (1260652-63-8) → 2-amino-N-(benzyloxy)-N-[3-(dimethylamino)propyl]octanamide dihydrochloride

Guidance literature:

With methanol; acetyl chloride; at 0 ℃; for 2h;

DOI:10.1016/j.bmc.2010.10.031

upstream raw materials:

2-((tertbutoxycarbonyl)amino)octanoic acid

Downstream raw materials:

3-[N-(benzyloxy)-2-(tert-butoxycarbonylamino)octanamido]-N,N,N-trimethylpropan-1-aminium iodide

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