tert-butyl-(1S,2S)-2-(4-(benzyloxy)phenylsulfonamido)-1,2-diphenylethylcarbamate

Base Information

• Chemical Name: tert-butyl-(1S,2S)-2-(4-(benzyloxy)phenylsulfonamido)-1,2-diphenylethylcarbamate
• CAS No.: 863483-29-8
• Molecular Formula: C₃₂H₃₄N₂O₅S
• Molecular Weight: 558.698
• Mol file: 863483-29-8.mol

Synonyms:tert-butyl-(1S,2S)-2-(4-(benzyloxy)phenylsulfonamido)-1,2-diphenylethylcarbamate

Chemical Property of tert-butyl-(1S,2S)-2-(4-(benzyloxy)phenylsulfonamido)-1,2-diphenylethylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of tert-butyl-(1S,2S)-2-(4-(benzyloxy)phenylsulfonamido)-1,2-diphenylethylcarbamate

There total 5 articles about tert-butyl-(1S,2S)-2-(4-(benzyloxy)phenylsulfonamido)-1,2-diphenylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-((1S,2S)-2-amino-1,2-diphenylethyl)-4-(benzyloxy)benzenesulfonamide (863483-28-7) + di-tert-butyl dicarbonate (24424-99-5) → tert-butyl-(1S,2S)-2-(4-(benzyloxy)phenylsulfonamido)-1,2-diphenylethylcarbamate (863483-29-8)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 4h;

DOI:10.1016/j.tetasy.2008.03.015

Reference yield:

benzyl bromide (100-39-0) → tert-butyl-(1S,2S)-2-(4-(benzyloxy)phenylsulfonamido)-1,2-diphenylethylcarbamate (863483-29-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / K₂CO₃; dibenzo-18-crown-6 / acetone / 48 h / Heating

2: 86 percent / SOCl₂ / dimethylformamide / 2 h / 60 °C

3: 65 percent / Et₃N / CH₂Cl₂ / 4 h / 20 °C

4: 95 percent / DIPEA / CH₂Cl₂ / 4 h / 20 °C

With dibenzo-18-crown-6; thionyl chloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1039/b505943g

Reference yield:

sodium p-hydroxybenzenesulfonate (825-90-1) → tert-butyl-(1S,2S)-2-(4-(benzyloxy)phenylsulfonamido)-1,2-diphenylethylcarbamate (863483-29-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 99 percent / K₂CO₃; dibenzo-18-crown-6 / acetone / 48 h / Heating

2: 86 percent / SOCl₂ / dimethylformamide / 2 h / 60 °C

3: 65 percent / Et₃N / CH₂Cl₂ / 4 h / 20 °C

4: 95 percent / DIPEA / CH₂Cl₂ / 4 h / 20 °C

With dibenzo-18-crown-6; thionyl chloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1039/b505943g

upstream raw materials:

N-((1S,2S)-2-amino-1,2-diphenylethyl)-4-(benzyloxy)benzenesulfonamide

di-tert-butyl dicarbonate

benzyl bromide

sodium p-hydroxybenzenesulfonate

Downstream raw materials:

tert-butyl-(1S,2S)-2-(4-hydroxyphenylsulfonamido)-1,2-diphenylethylcarbamate

3-[4-((1S,2S)-2-tert-Butoxycarbonylamino-1,2-diphenyl-ethylsulfamoyl)-phenoxy]-propionic acid