tert-butyl-(1S,2S)-2-(4-(benzyloxy)phenylsulfonamido)-1,2-diphenylethylcarbamate

Base Information

Chemical Name:tert-butyl-(1S,2S)-2-(4-(benzyloxy)phenylsulfonamido)-1,2-diphenylethylcarbamate
CAS No.:863483-29-8
Molecular Formula:C₃₂H₃₄N₂O₅S
Molecular Weight:558.698
Hs Code.:

Synonyms:tert-butyl-(1S,2S)-2-(4-(benzyloxy)phenylsulfonamido)-1,2-diphenylethylcarbamate

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Chemical Property of tert-butyl-(1S,2S)-2-(4-(benzyloxy)phenylsulfonamido)-1,2-diphenylethylcarbamate

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Technology Process of tert-butyl-(1S,2S)-2-(4-(benzyloxy)phenylsulfonamido)-1,2-diphenylethylcarbamate

There total 5 articles about tert-butyl-(1S,2S)-2-(4-(benzyloxy)phenylsulfonamido)-1,2-diphenylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 863483-28-7
N-((1S,2S)-2-amino-1,2-diphenylethyl)-4-(benzyloxy)benzenesulfonamide

: 24424-99-5
di-tert-butyl dicarbonate

: 863483-29-8
tert-butyl-(1S,2S)-2-(4-(benzyloxy)phenylsulfonamido)-1,2-diphenylethylcarbamate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 4h;
DOI:10.1016/j.tetasy.2008.03.015

Reference yield:

: 100-39-0
benzyl bromide

: 863483-29-8
tert-butyl-(1S,2S)-2-(4-(benzyloxy)phenylsulfonamido)-1,2-diphenylethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / K₂CO₃; dibenzo-18-crown-6 / acetone / 48 h / Heating

2: 86 percent / SOCl₂ / dimethylformamide / 2 h / 60 °C

3: 65 percent / Et₃N / CH₂Cl₂ / 4 h / 20 °C

4: 95 percent / DIPEA / CH₂Cl₂ / 4 h / 20 °C

With dibenzo-18-crown-6; thionyl chloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1039/b505943g

Reference yield:

: 825-90-1
sodium p-hydroxybenzenesulfonate

: 863483-29-8
tert-butyl-(1S,2S)-2-(4-(benzyloxy)phenylsulfonamido)-1,2-diphenylethylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / K₂CO₃; dibenzo-18-crown-6 / acetone / 48 h / Heating

2: 86 percent / SOCl₂ / dimethylformamide / 2 h / 60 °C

3: 65 percent / Et₃N / CH₂Cl₂ / 4 h / 20 °C

4: 95 percent / DIPEA / CH₂Cl₂ / 4 h / 20 °C

With dibenzo-18-crown-6; thionyl chloride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; acetone;
DOI:10.1039/b505943g