1,1-dimethylethyl [(1S)-2-({(3S)-1-[2-cyano-4-(phenyloxy)phenyl]-3-pyrrolidinyl}amino)-2-oxo-1-(2-thienylmethyl)ethyl]carbamate

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Chemical Name:1,1-dimethylethyl [(1S)-2-({(3S)-1-[2-cyano-4-(phenyloxy)phenyl]-3-pyrrolidinyl}amino)-2-oxo-1-(2-thienylmethyl)ethyl]carbamate
CAS No.:1269407-64-8
Molecular Formula:C₂₉H₃₂N₄O₄S
Molecular Weight:532.663
Hs Code.:

Synonyms:1,1-dimethylethyl [(1S)-2-({(3S)-1-[2-cyano-4-(phenyloxy)phenyl]-3-pyrrolidinyl}amino)-2-oxo-1-(2-thienylmethyl)ethyl]carbamate

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Chemical Property of 1,1-dimethylethyl [(1S)-2-({(3S)-1-[2-cyano-4-(phenyloxy)phenyl]-3-pyrrolidinyl}amino)-2-oxo-1-(2-thienylmethyl)ethyl]carbamate

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Technology Process of 1,1-dimethylethyl [(1S)-2-({(3S)-1-[2-cyano-4-(phenyloxy)phenyl]-3-pyrrolidinyl}amino)-2-oxo-1-(2-thienylmethyl)ethyl]carbamate

There total 7 articles about 1,1-dimethylethyl [(1S)-2-({(3S)-1-[2-cyano-4-(phenyloxy)phenyl]-3-pyrrolidinyl}amino)-2-oxo-1-(2-thienylmethyl)ethyl]carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 56675-37-7
(S)-2-tert-butoxycarbonylamino-3-thiophen-2-yl-propionic acid

: 1269407-63-7
2-[(3S)-3-amino-1-pyrrolidinyl]-5-(phenyloxy)benzonitrile hydrochloride

: 1269407-64-8
1,1-dimethylethyl [(1S)-2-({(3S)-1-[2-cyano-4-(phenyloxy)phenyl]-3-pyrrolidinyl}amino)-2-oxo-1-(2-thienylmethyl)ethyl]carbamate

Guidance literature:: With triethylamine; HATU; In dichloromethane; at 20 ℃; for 2.25h;

Reference yield:

: 108-95-2,27073-41-2
phenol

: 1269407-64-8
1,1-dimethylethyl [(1S)-2-({(3S)-1-[2-cyano-4-(phenyloxy)phenyl]-3-pyrrolidinyl}amino)-2-oxo-1-(2-thienylmethyl)ethyl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / tetrahydrofuran / 0.83 h / 20 °C

2: hydrogen / 20 wt% Pd(OH)2/C / methanol / 3.5 h / 20 °C

3: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 0.17 h / 0 - 20 °C

4: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 19.5 h / 100 °C / Inert atmosphere

5: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

6: triethylamine; HATU / dichloromethane / 2.25 h / 20 °C

With hydrogenchloride; tert.-butylnitrite; hydrogen; sodium hydride; caesium carbonate; triethylamine; HATU; copper(ll) bromide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 20 wt% Pd(OH)2/C; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 50594-78-0
5-fluoro-2-nitrobenzonitrile

: 1269407-64-8
1,1-dimethylethyl [(1S)-2-({(3S)-1-[2-cyano-4-(phenyloxy)phenyl]-3-pyrrolidinyl}amino)-2-oxo-1-(2-thienylmethyl)ethyl]carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / tetrahydrofuran / 0.83 h / 20 °C

2: hydrogen / 20 wt% Pd(OH)2/C / methanol / 3.5 h / 20 °C

3: copper(ll) bromide; tert.-butylnitrite / acetonitrile / 0.17 h / 0 - 20 °C

4: caesium carbonate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / toluene / 19.5 h / 100 °C / Inert atmosphere

5: hydrogenchloride / 1,4-dioxane / 1 h / 20 °C

6: triethylamine; HATU / dichloromethane / 2.25 h / 20 °C

With hydrogenchloride; tert.-butylnitrite; hydrogen; sodium hydride; caesium carbonate; triethylamine; HATU; copper(ll) bromide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 20 wt% Pd(OH)2/C; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; toluene; acetonitrile;