2-(3-phenylacetamido-4-thiobenzyl-(3R,4R)-azetidin-2-on-1-yl)-phthalidyl acetate

Base Information

Chemical Name:2-(3-phenylacetamido-4-thiobenzyl-(3R,4R)-azetidin-2-on-1-yl)-phthalidyl acetate
CAS No.:202919-22-0
Molecular Formula:C₂₈H₂₄N₂O₆S
Molecular Weight:516.574
Hs Code.:

Synonyms:2-(3-phenylacetamido-4-thiobenzyl-(3R,4R)-azetidin-2-on-1-yl)-phthalidyl acetate

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Chemical Property of 2-(3-phenylacetamido-4-thiobenzyl-(3R,4R)-azetidin-2-on-1-yl)-phthalidyl acetate

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Technology Process of 2-(3-phenylacetamido-4-thiobenzyl-(3R,4R)-azetidin-2-on-1-yl)-phthalidyl acetate

There total 4 articles about 2-(3-phenylacetamido-4-thiobenzyl-(3R,4R)-azetidin-2-on-1-yl)-phthalidyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 100-39-0
benzyl bromide

: 122691-76-3,122743-52-6
2-<3-phenylacetamido-4-thiol-(3R,4R)-azetidin-2-on-1-yl>-phthalidyl acetate

: 202919-22-0
2-(3-phenylacetamido-4-thiobenzyl-(3R,4R)-azetidin-2-on-1-yl)-phthalidyl acetate

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 0 ℃; for 1h; then 20 deg C;
DOI:10.1016/0223-5234(88)90100-6

Reference yield:

: 87996-80-3
2-<3-benzyl-6-oxo-2-thia-4,7-diaza-(1R,5R)-bicyclo-<3.2.0>-hept-3-en-7-yl>-acetic acid

: 202919-22-0
2-(3-phenylacetamido-4-thiobenzyl-(3R,4R)-azetidin-2-on-1-yl)-phthalidyl acetate

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent

2: 92 percent / 1.2 N aq HCl / dimethylformamide / 1 h / Ambient temperature

3: 77 percent / triethylamine / dimethylformamide / 1 h / 0 °C / then 20 deg C

With hydrogenchloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(88)90100-6

Reference yield:

: 122692-65-3,124223-93-4
2-<3-benzyl-6-oxo-2-thia-4,7-diaza-(1R,5R)-bicyclo-<3,2,0>-hept-3-en-7-yl>-phthalidyl acetate

: 202919-22-0
2-(3-phenylacetamido-4-thiobenzyl-(3R,4R)-azetidin-2-on-1-yl)-phthalidyl acetate

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / 1.2 N aq HCl / dimethylformamide / 1 h / Ambient temperature

2: 77 percent / triethylamine / dimethylformamide / 1 h / 0 °C / then 20 deg C

With hydrogenchloride; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1016/0223-5234(88)90100-6