{4-[3-chloro-2-(5-methyl-oxazol-2-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester

Base Information

Chemical Name:{4-[3-chloro-2-(5-methyl-oxazol-2-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester
CAS No.:1374454-18-8
Molecular Formula:C₂₄H₂₄ClN₃O₃
Molecular Weight:437.926
Hs Code.:

Synonyms:{4-[3-chloro-2-(5-methyl-oxazol-2-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester

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Chemical Property of {4-[3-chloro-2-(5-methyl-oxazol-2-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester

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Technology Process of {4-[3-chloro-2-(5-methyl-oxazol-2-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester

There total 4 articles about {4-[3-chloro-2-(5-methyl-oxazol-2-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 489446-42-6
4-((tert-butoxycarbonylamino)methyl)phenylboronic acid

: 1374454-16-6
3-chloro-2-(5-methyl-oxazol-2-yl)-indole

: 1374454-18-8
{4-[3-chloro-2-(5-methyl-oxazol-2-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; copper diacetate; In N,N-dimethyl-formamide; at 20 ℃; for 144h; Molecular sieve;

Reference yield:

: 28737-32-8
3-chloro-1H-indole-2-carboxylic acid

: 1374454-18-8
{4-[3-chloro-2-(5-methyl-oxazol-2-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C / Reflux

1.2: 1 h / 0 - 20 °C / Inert atmosphere

2.1: Burgess Reagent / tetrahydrofuran / 0.28 h / 120 °C / Inert atmosphere; microwave oven

3.1: N-ethyl-N,N-diisopropylamine / copper diacetate / N,N-dimethyl-formamide / 144 h / 20 °C / Molecular sieve

With oxalyl dichloride; Burgess Reagent; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; copper diacetate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 1374454-18-8
{4-[3-chloro-2-(5-methyl-oxazol-2-yl)-indol-1-yl]-benzyl}-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-chloro-succinimide / acetonitrile / 5 h / Reflux

2.1: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 2 h / 20 °C / Reflux

2.2: 1 h / 0 - 20 °C / Inert atmosphere

3.1: Burgess Reagent / tetrahydrofuran / 0.28 h / 120 °C / Inert atmosphere; microwave oven

4.1: N-ethyl-N,N-diisopropylamine / copper diacetate / N,N-dimethyl-formamide / 144 h / 20 °C / Molecular sieve

With N-chloro-succinimide; oxalyl dichloride; Burgess Reagent; N-ethyl-N,N-diisopropylamine; N,N-dimethyl-formamide; copper diacetate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetonitrile;