Acetic acid (R)-1-acetoxymethyl-2-(4-methoxy-phenoxy)-ethyl ester

Base Information

• Chemical Name: Acetic acid (R)-1-acetoxymethyl-2-(4-methoxy-phenoxy)-ethyl ester
• CAS No.: 130998-37-7
• Molecular Formula: C₁₄H₁₈O₆
• Molecular Weight: 282.293
• Mol file: 130998-37-7.mol

Synonyms:Acetic acid (R)-1-acetoxymethyl-2-(4-methoxy-phenoxy)-ethyl ester

Chemical Property of Acetic acid (R)-1-acetoxymethyl-2-(4-methoxy-phenoxy)-ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (R)-1-acetoxymethyl-2-(4-methoxy-phenoxy)-ethyl ester

There total 6 articles about Acetic acid (R)-1-acetoxymethyl-2-(4-methoxy-phenoxy)-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

vinyl acetate (108-05-4,9003-20-7) + 3-(4-methoxyphenoxy)-1,2-propanediol (17131-52-1) → Acetic acid (R)-1-acetoxymethyl-2-(4-methoxy-phenoxy)-ethyl ester (130998-37-7) + (S)-1,2-Diacetoxy-3-(4-methoxyphenyl)-propane (147220-38-0) + (R/S)-Acetoxy-3-(4-methoxyphenyl)-2-propanol

Guidance literature:

With triethylamine; In tetrahydrofuran; for 100h; Yield given. Yields of byproduct given. Title compound not separated from byproducts; lipase amano PS;

DOI:10.1021/jo00081a018

Reference yield:

(R)-1,2-O-isopropylidene-3-O-(4-methoxyphenyl)glycerol (130998-32-2) → Acetic acid (R)-1-acetoxymethyl-2-(4-methoxy-phenoxy)-ethyl ester (130998-37-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 1N aq. H₂SO₄ / 0.83 h / Heating

2: 98 percent / pyridine / CH₂Cl₂ / 8 h / Ambient temperature

3: potassium acetate / 1.67 h / Heating

With pyridine; sulfuric acid; potassium acetate; In dichloromethane;

DOI:10.3987/COM-90-5476

Reference yield:

(R)-3-(p-methoxyphenoxy)-1,2-propanediol (17131-52-1,124933-35-3,131064-88-5,131064-87-4) → Acetic acid (R)-1-acetoxymethyl-2-(4-methoxy-phenoxy)-ethyl ester (130998-37-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / pyridine / CH₂Cl₂ / 8 h / Ambient temperature

2: potassium acetate / 1.67 h / Heating

With pyridine; potassium acetate; In dichloromethane;

DOI:10.3987/COM-90-5476

upstream raw materials:

vinyl acetate

3-(4-methoxyphenoxy)-1,2-propanediol

acetic anhydride

Methanesulfonic acid (S)-2-methanesulfonyloxy-1-(4-methoxy-phenoxymethyl)-ethyl ester

Downstream raw materials:

(S)-1-O-(4-methoxyphenyl)glycerol

(2S)-2-{[4-(methoxy)phenoxy]methyl}oxirane

(R)-4-(4-Methoxy-phenoxymethyl)-2-phenyl-[1,3]dioxolane

Benzoic acid (R)-1-bromomethyl-2-(4-methoxy-phenoxy)-ethyl ester