130998-32-2

Basic information

• Product Name: (R)-1,2-O-isopropylidene-3-O-(4-methoxyphenyl)glycerol
• Synonyms: (R)-1,2-O-isopropylidene-3-O-(4-methoxyphenyl)glycerol
• CAS NO: 130998-32-2
• Molecular Weight: 238.284
• Mol File: 130998-32-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (R)-1,2-O-isopropylidene-3-O-(4-methoxyphenyl)glycerol(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1,2-O-isopropylidene-3-O-(4-methoxyphenyl)glycerol(130998-32-2)
• EPA Substance Registry System: (R)-1,2-O-isopropylidene-3-O-(4-methoxyphenyl)glycerol(130998-32-2)

Safety Data

• Hazardous Substances Data: 130998-32-2(Hazardous Substances Data)

Upstream product

• 22323-82-6 (S)-(+)-(2,2-dimethyl-[1,3]dioxolan-4-yl)methanol 
• 150-76-5 4-methoxy-phenol 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 623-12-1 4-chloromethoxybenzene 
• 23788-74-1 (R)-2,2-dimethyl-1,3-dioxolane-4-ylmethyl p-toluenesulfonate 

Downstream Products

• 955948-40-0 C₃₀H₃₀O₅ 
• 130998-34-4 Benzoic acid (S)-1-bromomethyl-2-(4-methoxy-phenoxy)-ethyl ester 
• 130998-34-4 Benzoic acid (R)-1-bromomethyl-2-(4-methoxy-phenoxy)-ethyl ester 
• 130998-33-3 (2R/S,4S)-4-(4-methoxyphenyl)-2-phenyl-1,3-dioxolane 
• 130998-33-3 (R)-4-(4-Methoxy-phenoxymethyl)-2-phenyl-[1,3]dioxolane 
• 17131-52-1 (S)-1-O-(4-methoxyphenyl)glycerol 
• 2211-94-1 4-methoxybenzyloxy ester of (S)-glycidol 
• 2211-94-1 (2S)-2-{[4-(methoxy)phenoxy]methyl}oxirane 
• 130998-35-5 Toluene-4-sulfonic acid (S)-2-hydroxy-3-(4-methoxy-phenoxy)-propyl ester 
• 130998-36-6 Methanesulfonic acid (S)-2-methanesulfonyloxy-1-(4-methoxy-phenoxymethyl)-ethyl ester 
• 130998-37-7 Acetic acid (R)-1-acetoxymethyl-2-(4-methoxy-phenoxy)-ethyl ester 
• 17131-52-1 (R)-3-(p-methoxyphenoxy)-1,2-propanediol 

Relevant articles and documents

Structure-activity relationships of lysophosphatidylserine analogs as agonists of G-protein-coupled receptors GPR34, P2Y10, and GPR174

Lysophosphatidylserine (LysoPS) is an endogenous lipid mediator generated by hydrolysis of membrane phospholipid phosphatidylserine. Recent ligand screening of orphan G-protein-coupled receptors (GPCRs) identified two LysoPS-specific human GPCRs, namely, P2Y10 (LPS2) and GPR174 (LPS3), which, together with previously reported GPR34 (LPS1), comprise a LysoPS receptor family. Herein, we examined the structure-activity relationships of a series of synthetic LysoPS analogues toward these recently deorphanized LysoPS receptors, based on the idea that LysoPS can be regarded as consisting of distinct modules (fatty acid, glycerol, and l-serine) connected by phosphodiester and ester linkages. Starting from the endogenous ligand (1-oleoyl-LysoPS, 1), we optimized the structure of each module and the ester linkage. Accordingly, we identified some structural requirements of each module for potency and for receptor subtype selectivity. Further assembly of individually structure-optimized modules yielded a series of potent and LysoPS receptor subtype-selective agonists, particularly for P2Y10 and GPR174.

GLYCERO-COMPOUND HAVING TRIPLE BOND AND MEMBRANE MATERIAL CONTAINING THE SAME

The present invention provides a chemically stable and novel glycero-compound having one or two triple bonds, one molecule of a glycerol and one or two molecules of a fatty alcohol having a triple bond being linked through an ether bond, an organic group being linked to residual hydroxyl groups of the glycerol, which can be used as a membrane material for forming a vesicle membrane due to its high intermolecular cohesive force, and also provides a membrane forming material containing the same. The glycero-compound has a triple bond represented by the following general formula (1): wherein n and m each represents a number of 1 to 17 and the total (n+m) is a number of 4 to 18, n and m may be the same or different, and R represents a hydrogen atom, a metal atom, a phosphoric acid group, or an organic group which may be linked through a phosphoric acid group.

PRACTICAL ROUTE TO BOTH (S)- AND (R)-ENANTIOMERS OF O-(4-METHOXYPHENYL)GLYCIDOL USING (S)-1,2-O-ISOPROPYLIDENEGLYCEROL AS A COMMON PRECURSOR

Practical route to both (R)- and (S)-enantiomers of O-(4-methoxyphenyl)glycidol is devised using (S)-1,2-O-isopropylideneglycerol as a common chiral starting material.