(E)-1-(4-(7-chloroquinolin-4-ylamino)butyl)-3-(4-(2,5-dichlorophenoxy)phenyl)-2-phenylguanidine

Base Information

Chemical Name:(E)-1-(4-(7-chloroquinolin-4-ylamino)butyl)-3-(4-(2,5-dichlorophenoxy)phenyl)-2-phenylguanidine
CAS No.:1596271-77-0
Molecular Formula:C₃₂H₂₈Cl₃N₅O
Molecular Weight:604.966
Hs Code.:

Synonyms:(E)-1-(4-(7-chloroquinolin-4-ylamino)butyl)-3-(4-(2,5-dichlorophenoxy)phenyl)-2-phenylguanidine

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Chemical Property of (E)-1-(4-(7-chloroquinolin-4-ylamino)butyl)-3-(4-(2,5-dichlorophenoxy)phenyl)-2-phenylguanidine

Chemical Property:

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Technology Process of (E)-1-(4-(7-chloroquinolin-4-ylamino)butyl)-3-(4-(2,5-dichlorophenoxy)phenyl)-2-phenylguanidine

There total 5 articles about (E)-1-(4-(7-chloroquinolin-4-ylamino)butyl)-3-(4-(2,5-dichlorophenoxy)phenyl)-2-phenylguanidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 1596271-22-5
1-(4-(2,5-dichlorophenoxy)phenyl)-3-phenylthiourea

: 53186-45-1
N₁-(7-chloroquinolin-4-yl)butane-1,4-diamine

: 1596271-77-0
(E)-1-(4-(7-chloroquinolin-4-ylamino)butyl)-3-(4-(2,5-dichlorophenoxy)phenyl)-2-phenylguanidine

Guidance literature:: With triethylamine; mercury dichloride; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmcl.2014.02.044

Reference yield:

: 61575-24-4
4-(2,5-dichlorophenoxy)aniline

: 1596271-77-0
(E)-1-(4-(7-chloroquinolin-4-ylamino)butyl)-3-(4-(2,5-dichlorophenoxy)phenyl)-2-phenylguanidine

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-formamide / 20 °C

2: triethylamine; mercury dichloride / N,N-dimethyl-formamide / 20 °C

With triethylamine; mercury dichloride; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.02.044

Reference yield:

: 583-78-8
2,5-dichlorophenol

: 1596271-77-0
(E)-1-(4-(7-chloroquinolin-4-ylamino)butyl)-3-(4-(2,5-dichlorophenoxy)phenyl)-2-phenylguanidine

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2: iron; acetic acid / 0.33 h / 90 °C

3: N,N-dimethyl-formamide / 20 °C

4: triethylamine; mercury dichloride / N,N-dimethyl-formamide / 20 °C

With iron; potassium carbonate; acetic acid; triethylamine; mercury dichloride; In N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.02.044