61575-24-4

Upstream product

• 350-46-9 4-Fluoronitrobenzene 
• 583-78-8 2,5-dichlorophenol 
• 39145-48-7 1,4-dichloro-2-(4-nitrophenoxy)benzene 

Downstream Products

• 23737-40-8 Cyclopropanecarboxylic acid [4-(2,5-dichloro-phenoxy)-phenyl]-amide 
• 1596271-73-6 (E)-1-(2-(7-chloroquinolin-4-ylamino)ethyl)-3-(4-(2,5-dichlorophenoxy)phenyl)-2-phenylguanidine 
• 1596271-75-8 (E)-1-(3-(7-chloroquinolin-4-ylamino)propyl)-3-(4-(2,5-dichlorophenoxy)phenyl)-2-phenylguanidine 
• 1596271-77-0 (E)-1-(4-(7-chloroquinolin-4-ylamino)butyl)-3-(4-(2,5-dichlorophenoxy)phenyl)-2-phenylguanidine 
• 1596271-79-2 (E)-2-(3-chlorophenyl)-1-(2-(7-chloroquinolin-4-ylamino)ethyl)-3-(4-(2,5-dichlorophenoxy)phenyl)guanidine 
• 1596271-81-6 (E)-2-(3-chlorophenyl)-1-(3-(7-chloroquinolin-4-ylamino)propyl)-3-(4-(2,5-dichlorophenoxy)phenyl)guanidine 
• 1596271-84-9 (E)-2-(3-chlorophenyl)-1-(4-(7-chloroquinolin-4-ylamino)butyl)-3-(4-(2,5-dichlorophenoxy)phenyl)guanidine 
• 1596271-87-2 (E)-2-(4-chlorophenyl)-1-(2-(7-chloroquinolin-4-ylamino)ethyl)-3-(4-(2,5-dichlorophenoxy)phenyl)guanidine 
• 1596271-90-7 (E)-2-(4-chlorophenyl)-1-(3-(7-chloroquinolin-4-ylamino)propyl)-3-(4-(2,5-dichlorophenoxy)phenyl)guanidine 
• 1596271-91-8 (E)-2-(4-chlorophenyl)-1-(4-(7-chloroquinolin-4-ylamino)butyl)-3-(4-(2,5-dichlorophenoxy)phenyl)guanidine 
• 1596271-23-6 1-(3-chlorophenyl)-3-(4-(2,5-dichlorophenoxy)phenyl)thiourea 
• 1596271-25-8 1-(4-chlorophenyl)-3-(4-(2,5-dichlorophenoxy)phenyl)thiourea 
• 1596271-22-5 1-(4-(2,5-dichlorophenoxy)phenyl)-3-phenylthiourea 

Relevant academic research and scientific papers

AGRICULTURAL CHEMICALS

The present invention relates to picolinic acid derivatives that are useful in treating fungal diseases ofplants.

Synthesis and evaluation of new diaryl ether and quinoline hybrids as potential antiplasmodial and antimicrobial agents

Synthesis and bioevaluation of new diaryl ether hybridized quinoline derivatives as antiplasmodial, antibacterial and antifungal agents is reported. It was encouraging to discover that several compounds displayed 2-3 folds better efficacy than chloroquine in chloroquine-resistant K1 strain of Plasmodium falciparum. Further, a few members of the library displayed good antibacterial efficacy against gram positive strains of bacteria but none of the compounds displayed any significant antifungal activity.

COMPOUNDS AND METHODS FOR PKC THETA INHIBITION

The present invention provides a method of selectively inhibiting PKC in the presence of PKC, by administering to a subject in need thereof, a therapeutically effective amount of a compound of Formula I. The present invention also provides a method of inhibiting cytokine synthesis in a T cell, a method of inhibiting T cell proliferation, and a method of inhibiting the replication of and cytokine production by T lymphocytes, while not stimulating or inhibiting the replication of B lymphocytes.