5-(4,4-dimethyl-2-oxazolin-2-yl)-2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran

Base Information

• Chemical Name: 5-(4,4-dimethyl-2-oxazolin-2-yl)-2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran
• CAS No.: 220658-26-4
• Molecular Formula: C₂₇H₃₁NO₅
• Molecular Weight: 449.547

Synonyms:5-(4,4-dimethyl-2-oxazolin-2-yl)-2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran

Chemical Property of 5-(4,4-dimethyl-2-oxazolin-2-yl)-2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran

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Technology Process of 5-(4,4-dimethyl-2-oxazolin-2-yl)-2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran

There total 3 articles about 5-(4,4-dimethyl-2-oxazolin-2-yl)-2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

t-butyl 4-(2-iodophenyloxy)butyrate (220658-25-3) + 5-(4,4-dimethyl-2-oxazolin-2-yl)-2-tri(1-butyl)stannylbenzofuran → 5-(4,4-dimethyl-2-oxazolin-2-yl)-2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran (220658-26-4)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 90 ℃; for 3h;

DOI:10.3987/COM-98-8342

Reference yield:

2-Iodophenol (533-58-4) → 5-(4,4-dimethyl-2-oxazolin-2-yl)-2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran (220658-26-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / K₂CO₃ / acetone / 6 h / Heating

2: 85 percent / Na₂CO₃ / (Ph₃P)4Pd / dimethylformamide / 3 h / 90 °C

With sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; acetone;

DOI:10.3987/COM-98-8342

Reference yield:

tert-butyl 4-bromobutyrate (110661-91-1) → 5-(4,4-dimethyl-2-oxazolin-2-yl)-2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran (220658-26-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / K₂CO₃ / acetone / 6 h / Heating

2: 85 percent / Na₂CO₃ / (Ph₃P)4Pd / dimethylformamide / 3 h / 90 °C

With sodium carbonate; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; acetone;

DOI:10.3987/COM-98-8342

upstream raw materials:

t-butyl 4-(2-iodophenyloxy)butyrate

2-Iodophenol

tert-butyl 4-bromobutyrate

Downstream raw materials:

N-diphenylmethyl-2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran-5-carboxamide

2-<2-<3-(tert-butyl)oxycarbonyl-1-propyloxy>phenyl>benzofuran-5-carboxylic acid

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