110661-91-1

Basic information

• Product Name: T-BUTYL 4-BROMOBUTYRATE
• Synonyms: Butanoic acid, 4-broMo-,1,1-diMethylethyl ester;tert-Butyl 4-bromobutanoate, tech;tert-Butyl4-bromobutanoate95%;4-Bromobutanoic acid tert-butyl ester
• CAS NO: 110661-91-1
• Molecular Formula: C₈H₁₅BrO₂
• Molecular Weight: 223.12
• Product Categories: Acids & Esters;Bromine Compounds
• Mol File: 110661-91-1.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 225.9 °C at 760 mmHg
• Flash Point: 117.1 °C
• Appearance: /
• Density: 1.258 g/cm³
• Vapor Pressure: 0.0843mmHg at 25°C
• Refractive Index: 1.46
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: T-BUTYL 4-BROMOBUTYRATE(CAS DataBase Reference)
• NIST Chemistry Reference: T-BUTYL 4-BROMOBUTYRATE(110661-91-1)
• EPA Substance Registry System: T-BUTYL 4-BROMOBUTYRATE(110661-91-1)

Safety Data

• Hazard Codes: Xi:Irritant
• Statements: 34-36/37/38
• Safety Statements: 22-26-36/37/39-45
• RIDADR: 1760
• HazardClass: 8
• PackingGroup: Ⅲ
• Hazardous Substances Data: 110661-91-1(Hazardous Substances Data)

Usage

Uses

t-Butyl 4-Bromobutyrate. is a potent CB1 receptor antagonist involved in the cannabinoid-1 receptor signalling process. Inhibition of this receptor has been demonstrated to inhibit feeding behaviors. Antiinflammatory.

InChI:InChI=1/C8H15BrO2/c1-8(2,3)11-7(10)5-4-6-9/h4-6H2,1-3H3

Upstream product

• 2623-87-2 bromobutyric acid 
• 115-11-7 isobutene 
• 59854-12-5 tert-butyl 4-hydroxybutyrate 
• 927-58-2 4-bromobutyroyl chloride 
• 865-47-4 potassium tert-butylate 
• 15026-17-2 succinic acid mono-tert-butyl ester 
• 75-65-0 tert-butyl alcohol 

Downstream Products

• 874210-16-9 2,4-bis[3-(tert-butoxycarbonyl)propoxy]-5-nitrobenzoic acid methyl ester 
• 1002566-64-4 tert-butyl 4-(3,3-diphenylpropylamino)butanoate 
• 731862-95-6 (4-(tert-butoxy)-4-oxobutyl)triphenylphosphonium bromide 
• 913368-44-2 ethyl 4-(4-tert-butoxy-4-oxobutoxy)-1-(2-chlorophenyl)-5-(4-chlorophenyl)-1H-pyrazole-3-carboxylate 
• 907184-96-7 dibenzyl (3-carboxypropyl)propanedioate 
• 1325728-38-8 C₃₀H₃₅N₃O₅ 
• 1192732-11-8 tert-butyl 4-{[3-[(4-chlorophenyl)sulfonyl]-3-(2,5-difluorophenyl)cyclobutyl][(trifluoromethyl)sulfonyl]amino}butanoate 
• 1259518-96-1 C₃₁H₄₈O₁₁ 
• 1259518-99-4 C₄₄H₆₅NO₁₂ 
• 1259519-00-0 C₃₇H₅₉NO₁₂ 
• 1259518-93-8 C₃₈H₅₄O₁₁ 
• 1466574-60-6 3-(3-tert-butoxycarbonylpropane-1-sulfonyl)-5-trifluoromethylbenzoic acid methyl ester 

Relevant articles and documents

DNA-templated synthesis of trimethine cyanine dyes: A versatile fluorogenic Reaction for sensing G-quadruplex formation

(Figure Presented) A healthy glow: Fluorogenic peptide nucleic acids (PNAs) functionalized with indoline derivatives are used to specifically sense G-quadruplex formation. Upon hybridization of both PNAs to the singlestranded flanking arms of quadruplex DNA (see scheme), the synthesis of a trimethine cyanine dye is templated. Dye formation can be detected by the appearance of a characteristic fluorescence signal.

Design and synthesis of triphenylphosphonium-porphyrin@xylan nanoparticles for anticancer photodynamic therapy

Most photosensitizers (PS) suffer from a lack of water solubility and from a low selectivity toward tumor cells. Delivery systems using nanoparticles make it possible to improve PS water solubility, and also tumor targeting via the enhanced permeability a

Spontaneously Blinking Fluorophores Based on Nucleophilic Addition/Dissociation of Intracellular Glutathione for Live-Cell Super-resolution Imaging

Single-molecule localization microscopy (SMLM) allows the reconstruction of super-resolution images but generally requires prior intense laser irradiation and in some cases additives to induce blinking of conventional fluorophores. We previously introduced a spontaneously blinking rhodamine fluorophore based on an intramolecular spirocyclization reaction for live-cell SMLM under physiological conditions. Here, we report a novel principle of spontaneous blinking in living cells, which utilizes reversible ground-state nucleophilic attack of intracellular glutathione (GSH) upon a xanthene fluorophore. Structural optimization afforded two pyronine fluorophores with different colors, both of which exhibit equilibrium (between the fluorescent dissociated form and the nonfluorescent GSH adduct form) and blinking kinetics that enable SMLM of microtubules or mitochondria in living cells. Furthermore, by using spontaneously blinking fluorophores working in the near-infrared (NIR) and green ranges, we succeeded in dual-color live-cell SMLM without the need for optimization of the imaging medium.

Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)

The estrogen receptor (ER) is a validated target for the treatment of estrogen receptor-positive (ER+) breast cancer. Here, we describe the design, synthesis, and extensive structure-activity relationship (SAR) studies of small-molecule ERα degraders base