(S)-1-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]propan-2-ol

Base Information

Chemical Name:(S)-1-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]propan-2-ol
CAS No.:1005478-09-0
Molecular Formula:C₂₈H₄₀N₂O₆S
Molecular Weight:532.701
Hs Code.:

Synonyms:(S)-1-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]propan-2-ol

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Chemical Property of (S)-1-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]propan-2-ol

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Technology Process of (S)-1-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]propan-2-ol

There total 11 articles about (S)-1-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 959937-43-0
[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]acetaldehyde

: 75-16-1
methylmagnesium bromide

: 1005478-09-0
(S)-1-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]propan-2-ol

: 1005478-08-9
(R)-1-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]propan-2-ol

Guidance literature:: In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 1h;

Reference yield:

: 406945-58-2
1,3,4-trideoxynojirimycin

: 1005478-09-0
(S)-1-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]propan-2-ol

: 1005478-08-9
(R)-1-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]propan-2-ol

Guidance literature:: Multi-step reaction with 9 steps

1.1: hydrogenchloride; sodium carbonate / tetrahydrofuran; water / 22 h / 70 °C / pH 8

2.1: 1H-imidazole / N,N-dimethyl-formamide / 42 h / 20 °C

3.1: tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 0.25 h / 20 °C

3.2: 3 h / 20 °C

4.1: borane-THF / tetrahydrofuran / 2 - 8 h / 20 - 50 °C

5.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C

6.1: triethylamine / dichloromethane / 1 h / 0 °C

7.1: dimethyl sulfoxide / 20 h / 60 °C

8.1: diisobutylaluminium hydride / dichloromethane / 2 h / -30 °C

9.1: tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C

With 1H-imidazole; hydrogenchloride; borane-THF; tetrabutyl ammonium fluoride; tetra-(n-butyl)ammonium iodide; diisobutylaluminium hydride; sodium carbonate; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 959937-48-5
4-(3-methoxypropyl)-6-[(3R,6S)-1-(toluene-4-sulphonyl)-6-triisopropylsilanyloxy-methylpiperidin-3-yloxymethyl]-4H-benzo[1,4]oxazin-3-one

: 1005478-09-0
(S)-1-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]propan-2-ol

: 1005478-08-9
(R)-1-[(2S,5R)-5-[4-(3-methoxypropyl)-3,4-dihydro-2H-benzo[1,4]oxazin-6-ylmethoxy]-1-(toluene-4-sulphonyl)piperidin-2-yl]propan-2-ol

Guidance literature:: Multi-step reaction with 6 steps

1: borane-THF / tetrahydrofuran / 2 - 8 h / 20 - 50 °C

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 18 h / 20 °C

3: triethylamine / dichloromethane / 1 h / 0 °C

4: dimethyl sulfoxide / 20 h / 60 °C

5: diisobutylaluminium hydride / dichloromethane / 2 h / -30 °C

6: tetrahydrofuran; diethyl ether / 1 h / 0 - 20 °C

With borane-THF; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide;