(S)-tert-butyl 1-(4-(4-cyano-3-fluorophenyl)-1H-imidazol-2-yl)-2-phenylethylcarbamate

Base Information

Chemical Name:(S)-tert-butyl 1-(4-(4-cyano-3-fluorophenyl)-1H-imidazol-2-yl)-2-phenylethylcarbamate
CAS No.:872017-92-0
Molecular Formula:C₂₃H₂₃FN₄O₂
Molecular Weight:406.46
Hs Code.:

Synonyms:(S)-tert-butyl 1-(4-(4-cyano-3-fluorophenyl)-1H-imidazol-2-yl)-2-phenylethylcarbamate

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Chemical Property of (S)-tert-butyl 1-(4-(4-cyano-3-fluorophenyl)-1H-imidazol-2-yl)-2-phenylethylcarbamate

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Technology Process of (S)-tert-butyl 1-(4-(4-cyano-3-fluorophenyl)-1H-imidazol-2-yl)-2-phenylethylcarbamate

There total 2 articles about (S)-tert-butyl 1-(4-(4-cyano-3-fluorophenyl)-1H-imidazol-2-yl)-2-phenylethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 872018-43-4
(S)-2-(4-cyano-3-fluorophenyl)-2-oxoethyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate

: 872017-92-0
(S)-tert-butyl 1-(4-(4-cyano-3-fluorophenyl)-1H-imidazol-2-yl)-2-phenylethylcarbamate

Guidance literature:: With ammonium acetate; In 5,5-dimethyl-1,3-cyclohexadiene; at 150 ℃; for 2.5h; Inert atmosphere; Dean-Stark;
DOI:10.1021/jm5010607

Reference yield:

: 366790-50-3
4-(2-bromoacetyl)-2-fluorobenzonitrile

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 872017-92-0
(S)-tert-butyl 1-(4-(4-cyano-3-fluorophenyl)-1H-imidazol-2-yl)-2-phenylethylcarbamate

Guidance literature:: 4-(2-bromoacetyl)-2-fluorobenzonitrile; N-tert-butoxycarbonyl-L-phenylalanine; With caesium carbonate; In N,N-dimethyl-formamide; at 15 ℃; for 1h;

With ammonium acetate; In xylene; at 150 ℃; for 2.5h;