(S)-2-(4-cyano-3-fluorophenyl)-2-oxoethyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate

Base Information

Chemical Name:(S)-2-(4-cyano-3-fluorophenyl)-2-oxoethyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate
CAS No.:872018-43-4
Molecular Formula:C₂₃H₂₃FN₂O₅
Molecular Weight:426.444
Hs Code.:

Synonyms:(S)-2-(4-cyano-3-fluorophenyl)-2-oxoethyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-2-(4-cyano-3-fluorophenyl)-2-oxoethyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate

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Technology Process of (S)-2-(4-cyano-3-fluorophenyl)-2-oxoethyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate

There total 4 articles about (S)-2-(4-cyano-3-fluorophenyl)-2-oxoethyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 366790-50-3
4-(2-bromoacetyl)-2-fluorobenzonitrile

: 13734-34-4
N-tert-butoxycarbonyl-L-phenylalanine

: 872018-43-4
(S)-2-(4-cyano-3-fluorophenyl)-2-oxoethyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 15 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm5010607

Reference yield:

: 176508-81-9
4-cyano-3-fluorobenzoic acid

: 872018-43-4
(S)-2-(4-cyano-3-fluorophenyl)-2-oxoethyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride / dichloromethane / 2 h / 20 °C / Inert atmosphere; Reflux

2.1: acetonitrile; hexane / 1.33 h / -15 °C / Inert atmosphere

2.2: 0.67 h / -15 °C / Inert atmosphere

3.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 15 °C / Inert atmosphere

With oxalyl dichloride; caesium carbonate; In hexane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm5010607

Reference yield:

: 177787-22-3
4-cyano-3-fluoro-benzoyl chloride

: 872018-43-4
(S)-2-(4-cyano-3-fluorophenyl)-2-oxoethyl 2-(tertbutoxycarbonylamino)-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetonitrile; hexane / 1.33 h / -15 °C / Inert atmosphere

1.2: 0.67 h / -15 °C / Inert atmosphere

2.1: caesium carbonate / N,N-dimethyl-formamide / 1 h / 15 °C / Inert atmosphere

With caesium carbonate; In hexane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm5010607