1,1-dimethylethyl (2-bromo-1,3-thiazol-5-yl)((2S)-2-((((1,1-dimethylethyl)oxy)carbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propyl)-carbamate

Base Information

Chemical Name:1,1-dimethylethyl (2-bromo-1,3-thiazol-5-yl)((2S)-2-((((1,1-dimethylethyl)oxy)carbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propyl)-carbamate
CAS No.:1105710-21-1
Molecular Formula:C₂₃H₂₉BrF₃N₃O₄S
Molecular Weight:580.466
Hs Code.:

Synonyms:1,1-dimethylethyl (2-bromo-1,3-thiazol-5-yl)((2S)-2-((((1,1-dimethylethyl)oxy)carbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propyl)-carbamate

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Chemical Property of 1,1-dimethylethyl (2-bromo-1,3-thiazol-5-yl)((2S)-2-((((1,1-dimethylethyl)oxy)carbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propyl)-carbamate

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Technology Process of 1,1-dimethylethyl (2-bromo-1,3-thiazol-5-yl)((2S)-2-((((1,1-dimethylethyl)oxy)carbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propyl)-carbamate

There total 2 articles about 1,1-dimethylethyl (2-bromo-1,3-thiazol-5-yl)((2S)-2-((((1,1-dimethylethyl)oxy)carbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propyl)-carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 1104069-86-4
(R,S)-tert-butyl-(S)-4-(4-trifluoromethylbenzyl)-1,2,3-oxathiazolidine-3-carboxylate-2-oxide

: 1094070-77-5
(2-bromo-thiazol-5-yl)-carbamic acid tert-butyl ester

: 1105710-21-1
1,1-dimethylethyl (2-bromo-1,3-thiazol-5-yl)((2S)-2-((((1,1-dimethylethyl)oxy)carbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propyl)-carbamate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃; for 1h;

Reference yield:

: 944805-79-2
tert-butyl (4S)-4-(4-(trifluoromethyl)benzyl)-1,2,3-oxathiazolidine-3-carboxylate 2,2-dioxide

: 1094070-77-5
(2-bromo-thiazol-5-yl)-carbamic acid tert-butyl ester

: 1105710-21-1
1,1-dimethylethyl (2-bromo-1,3-thiazol-5-yl)((2S)-2-((((1,1-dimethylethyl)oxy)carbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propyl)-carbamate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 50 ℃;
DOI:10.1016/j.bmcl.2010.01.067

Reference yield: 4.1%

: 899438-92-7
isoquinolin-6-ylboronic acid

: 1105710-21-1
1,1-dimethylethyl (2-bromo-1,3-thiazol-5-yl)((2S)-2-((((1,1-dimethylethyl)oxy)carbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propyl)-carbamate

: 1105710-22-2
1,1-dimethylethyl ((2S)-2-((((1,1-dimethylethyl)oxy)carbonyl)amino)-3-(4-(trifluoromethyl)phenyl)propyl)(2-(6-isoquinolinyl)-1,3-thiazol-5-yl)carbamate

Guidance literature:: With potassium acetate; bis[di-t-butyl(p-dimethylaminophenyl)phosphino]palladium (II) Dichloride; In water; acetonitrile; at 100 ℃; for 0.333333h; Microwave irradiation;