diisopropyl 1,1-difluoro-9-(5-methyl-2,4-dihydropyrimidin-1,3(2H)-yl)nonylphosphonate

Base Information

Chemical Name:diisopropyl 1,1-difluoro-9-(5-methyl-2,4-dihydropyrimidin-1,3(2H)-yl)nonylphosphonate
CAS No.:1363335-72-1
Molecular Formula:C₂₇H₃₉F₂N₂O₆P
Molecular Weight:556.587
Hs Code.:

Synonyms:diisopropyl 1,1-difluoro-9-(5-methyl-2,4-dihydropyrimidin-1,3(2H)-yl)nonylphosphonate

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Chemical Property of diisopropyl 1,1-difluoro-9-(5-methyl-2,4-dihydropyrimidin-1,3(2H)-yl)nonylphosphonate

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Technology Process of diisopropyl 1,1-difluoro-9-(5-methyl-2,4-dihydropyrimidin-1,3(2H)-yl)nonylphosphonate

There total 3 articles about diisopropyl 1,1-difluoro-9-(5-methyl-2,4-dihydropyrimidin-1,3(2H)-yl)nonylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1363335-66-3
diisopropyl 1,1-difluoro-9-bromononylphosphonate

: 4330-20-5
N-3-benzoylthymine

: 1363335-72-1
diisopropyl 1,1-difluoro-9-(5-methyl-2,4-dihydropyrimidin-1,3(2H)-yl)nonylphosphonate

Guidance literature:: With N,N,N',N'-tetramethylguanidine; In dimethyl sulfoxide; acetonitrile; at 20 ℃; for 15h;
DOI:10.1021/jm201694y

Reference yield:

: 4549-32-0
1,8-dibromooctane

: 1363335-72-1
diisopropyl 1,1-difluoro-9-(5-methyl-2,4-dihydropyrimidin-1,3(2H)-yl)nonylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C

1.2: 1.5 h / -78 - -10 °C

2.1: N,N,N',N'-tetramethylguanidine / dimethyl sulfoxide; acetonitrile / 15 h / 20 °C

With tert.-butyl lithium; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile; pentane;
DOI:10.1021/jm201694y

Reference yield:

: 327156-97-8
diisopropyl (methylsulfanyl)difluoromethylphosphonate

: 1363335-72-1
diisopropyl 1,1-difluoro-9-(5-methyl-2,4-dihydropyrimidin-1,3(2H)-yl)nonylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.17 h / -78 °C

1.2: 1.5 h / -78 - -10 °C

2.1: N,N,N',N'-tetramethylguanidine / dimethyl sulfoxide; acetonitrile / 15 h / 20 °C

With tert.-butyl lithium; N,N,N',N'-tetramethylguanidine; In tetrahydrofuran; dimethyl sulfoxide; acetonitrile; pentane;
DOI:10.1021/jm201694y