1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-3,4-dimethyl-5-(1-methylethyl)-1H-pyrrole

Base Information

Chemical Name:1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-3,4-dimethyl-5-(1-methylethyl)-1H-pyrrole
CAS No.:135833-79-3
Molecular Formula:C₂₀H₂₆FNO₂
Molecular Weight:331.43
Hs Code.:

Synonyms:1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-3,4-dimethyl-5-(1-methylethyl)-1H-pyrrole

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Chemical Property of 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-3,4-dimethyl-5-(1-methylethyl)-1H-pyrrole

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Technology Process of 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-3,4-dimethyl-5-(1-methylethyl)-1H-pyrrole

There total 4 articles about 1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-3,4-dimethyl-5-(1-methylethyl)-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 135833-80-6
[1-(2-[1,3]Dioxolan-2-yl-ethyl)-2-(4-fluoro-phenyl)-4-hydroxymethyl-5-isopropyl-1H-pyrrol-3-yl]-methanol

: 135833-79-3
1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-3,4-dimethyl-5-(1-methylethyl)-1H-pyrrole

Guidance literature:: With triethylsilane; trifluoroacetic acid; In dichloromethane; at 0 ℃; for 2h;
DOI:10.1021/jm00105a056

Reference yield:

: 5754-35-8
2-[1,3]dioxolan-2-yl-ethylamine

: 135833-79-3
1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-3,4-dimethyl-5-(1-methylethyl)-1H-pyrrole

Guidance literature:: Multi-step reaction with 6 steps

1: 55 percent / triethylamine / acetonitrile / 20 h / Heating

2: triethylamine / CH₂Cl₂ / 1.) 0 deg C, 50 min, 2.) RT, 60 min

3: NaOH / methanol; H₂O / 3 h / Heating

4: 89 percent / acetic anhydride / 2 h / Ambient temperature

5: 90 percent / lithium aluminum hydride / diethyl ether / 0.5 h / Heating

6: 71 percent / trifluoroacetic acid, triethylsilane / CH₂Cl₂ / 2 h / 0 °C

With triethylsilane; sodium hydroxide; lithium aluminium tetrahydride; acetic anhydride; triethylamine; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane; water; acetonitrile;
DOI:10.1021/jm00105a056

Reference yield:

: 104568-95-8
N-<2-(1,3-dioxolan-2-yl)ethyl>-DL-valine methyl ester

: 135833-79-3
1-<2-(1,3-dioxolan-2-yl)ethyl>-2-(4-fluorophenyl)-3,4-dimethyl-5-(1-methylethyl)-1H-pyrrole

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / CH₂Cl₂ / 1.) 0 deg C, 50 min, 2.) RT, 60 min

2: NaOH / methanol; H₂O / 3 h / Heating

3: 89 percent / acetic anhydride / 2 h / Ambient temperature

4: 90 percent / lithium aluminum hydride / diethyl ether / 0.5 h / Heating

5: 71 percent / trifluoroacetic acid, triethylsilane / CH₂Cl₂ / 2 h / 0 °C

With triethylsilane; sodium hydroxide; lithium aluminium tetrahydride; acetic anhydride; triethylamine; trifluoroacetic acid; In methanol; diethyl ether; dichloromethane; water;
DOI:10.1021/jm00105a056