8-(2'-Cyano-biphenyl-4-ylmethyl)-5-methyl-7-propyl-[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonic acid amide

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Chemical Name:8-(2'-Cyano-biphenyl-4-ylmethyl)-5-methyl-7-propyl-[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonic acid amide
CAS No.:148474-75-3
Molecular Formula:C₂₃H₂₂N₆O₂S
Molecular Weight:446.533
Hs Code.:

Synonyms:8-(2'-Cyano-biphenyl-4-ylmethyl)-5-methyl-7-propyl-[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonic acid amide

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Chemical Property of 8-(2'-Cyano-biphenyl-4-ylmethyl)-5-methyl-7-propyl-[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonic acid amide

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Technology Process of 8-(2'-Cyano-biphenyl-4-ylmethyl)-5-methyl-7-propyl-[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonic acid amide

There total 8 articles about 8-(2'-Cyano-biphenyl-4-ylmethyl)-5-methyl-7-propyl-[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 148474-70-8
8-<(2'-cyanobiphenyl-4-yl)methyl>-5-methyl-7-n-propyl-<1,2,4>-triazolo<1,5-c>pyrimidine-2-sulfonyl chloride

: 148474-75-3
8-(2'-Cyano-biphenyl-4-ylmethyl)-5-methyl-7-propyl-[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonic acid amide

Guidance literature:: With ammonia; In water; at 50 ℃; for 1h;
DOI:10.1021/jm00041a016

Reference yield:

: 114772-54-2
4'-(bromomethyl)-1,1'-biphenyl-2-carbonitrile

: 148474-75-3
8-(2'-Cyano-biphenyl-4-ylmethyl)-5-methyl-7-propyl-[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonic acid amide

Guidance literature:: Multi-step reaction with 7 steps

1: (i-Pr)2NEt, LiCl / tetrahydrofuran / 15 h / Heating

2: 1.) MeONa / 1.) MeOH, RT, 15 min, 2.) MeOH, a) RT, 20 h, b) reflux, 3 h

3: 98 percent / POCl₃ / 6 h / 100 °C

4: 92 percent / N₂H₄ / ethanol / 2 h / Heating

5: 86 percent / butan-1-ol / 3 h / Heating

6: 8 g / NaClO₃, conc. HCl / H₂O / 0.33 h / 0 °C

7: ammonia / H₂O / 1 h / 50 °C

With hydrogenchloride; sodium chlorate; ammonia; sodium methylate; N-ethyl-N,N-diisopropylamine; lithium chloride; hydrazine; trichlorophosphate; In tetrahydrofuran; ethanol; water; butan-1-ol;
DOI:10.1021/jm00041a016

Reference yield:

: 3249-68-1
ethyl butyroyl acetate

: 148474-75-3
8-(2'-Cyano-biphenyl-4-ylmethyl)-5-methyl-7-propyl-[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonic acid amide

Guidance literature:: Multi-step reaction with 7 steps

1: (i-Pr)2NEt, LiCl / tetrahydrofuran / 15 h / Heating

2: 1.) MeONa / 1.) MeOH, RT, 15 min, 2.) MeOH, a) RT, 20 h, b) reflux, 3 h

3: 98 percent / POCl₃ / 6 h / 100 °C

4: 92 percent / N₂H₄ / ethanol / 2 h / Heating

5: 86 percent / butan-1-ol / 3 h / Heating

6: 8 g / NaClO₃, conc. HCl / H₂O / 0.33 h / 0 °C

7: ammonia / H₂O / 1 h / 50 °C

With hydrogenchloride; sodium chlorate; ammonia; sodium methylate; N-ethyl-N,N-diisopropylamine; lithium chloride; hydrazine; trichlorophosphate; In tetrahydrofuran; ethanol; water; butan-1-ol;
DOI:10.1021/jm00041a016