Acetic acid (2R,3S)-3-acetoxymethyl-2-(3,4-dimethoxy-benzyl)-4-(3,4-dimethoxy-phenyl)-butyl ester

Base Information

• Chemical Name: Acetic acid (2R,3S)-3-acetoxymethyl-2-(3,4-dimethoxy-benzyl)-4-(3,4-dimethoxy-phenyl)-butyl ester
• CAS No.: 215377-58-5
• Molecular Formula: C₂₆H₃₄O₈
• Molecular Weight: 474.551
• Mol file: 215377-58-5.mol

Synonyms:Acetic acid (2R,3S)-3-acetoxymethyl-2-(3,4-dimethoxy-benzyl)-4-(3,4-dimethoxy-phenyl)-butyl ester

Chemical Property of Acetic acid (2R,3S)-3-acetoxymethyl-2-(3,4-dimethoxy-benzyl)-4-(3,4-dimethoxy-phenyl)-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (2R,3S)-3-acetoxymethyl-2-(3,4-dimethoxy-benzyl)-4-(3,4-dimethoxy-phenyl)-butyl ester

There total 2 articles about Acetic acid (2R,3S)-3-acetoxymethyl-2-(3,4-dimethoxy-benzyl)-4-(3,4-dimethoxy-phenyl)-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

meso-2,3-bis[(3,4-dimethoxyphenyl)methyl]-butane-1,4-diol (156769-15-2) + acetic anhydride (108-24-7) → Acetic acid (2R,3S)-3-acetoxymethyl-2-(3,4-dimethoxy-benzyl)-4-(3,4-dimethoxy-phenyl)-butyl ester (215377-58-5)

Guidance literature:

With pyridine; dmap; Ambient temperature;

DOI:10.1016/S0957-4166(98)00299-7

Reference yield:

meso-2,3-diveratryl-succinic acid dimethyl ester (163732-94-3) → Acetic acid (2R,3S)-3-acetoxymethyl-2-(3,4-dimethoxy-benzyl)-4-(3,4-dimethoxy-phenyl)-butyl ester (215377-58-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / LiAlH₄ / CH₂Cl₂; diethyl ether / Ambient temperature

2: 96 percent / pyridine, 4-dimethylaminopyridine / Ambient temperature

With pyridine; dmap; lithium aluminium tetrahydride; In diethyl ether; dichloromethane;

DOI:10.1016/S0957-4166(98)00299-7

Reference yield: 80.0%

Acetic acid (2R,3S)-3-acetoxymethyl-2-(3,4-dimethoxy-benzyl)-4-(3,4-dimethoxy-phenyl)-butyl ester (215377-58-5) → Acetic acid (2S,3R)-2-(3,4-dimethoxy-benzyl)-4-(3,4-dimethoxy-phenyl)-3-hydroxymethyl-butyl ester (215377-60-9)

Guidance literature:

With Candida antarctica lipase; ethanol; In di-isopropyl ether; benzene; for 23h; Ambient temperature;

DOI:10.1016/S0957-4166(98)00299-7

upstream raw materials:

meso-2,3-bis[(3,4-dimethoxyphenyl)methyl]-butane-1,4-diol

acetic anhydride

meso-2,3-diveratryl-succinic acid dimethyl ester

Downstream raw materials:

Acetic acid (2S,3R)-2-(3,4-dimethoxy-benzyl)-4-(3,4-dimethoxy-phenyl)-3-hydroxymethyl-butyl ester

(2R,3S)-4-Acetoxy-2,3-bis-(3,4-dimethoxy-benzyl)-butyric acid