2-(3-(benzyloxy)-6-chloropyridin-2-yl)-4-fluoro-1H-pyrrolo[2,3-c]pyridine

Base Information

• Chemical Name: 2-(3-(benzyloxy)-6-chloropyridin-2-yl)-4-fluoro-1H-pyrrolo[2,3-c]pyridine
• CAS No.: 1427034-48-7
• Molecular Formula: C₁₉H₁₃ClFN₃O
• Molecular Weight: 353.783

Synonyms:2-(3-(benzyloxy)-6-chloropyridin-2-yl)-4-fluoro-1H-pyrrolo[2,3-c]pyridine

Chemical Property of 2-(3-(benzyloxy)-6-chloropyridin-2-yl)-4-fluoro-1H-pyrrolo[2,3-c]pyridine

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Technology Process of 2-(3-(benzyloxy)-6-chloropyridin-2-yl)-4-fluoro-1H-pyrrolo[2,3-c]pyridine

There total 2 articles about 2-(3-(benzyloxy)-6-chloropyridin-2-yl)-4-fluoro-1H-pyrrolo[2,3-c]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 25.0%

2,2,2-trifluoro-N-(5-fluoro-4-iodopyridin-3-yl)acetamide (1427035-53-7) + 3-(benzyloxy)-2-ethynyl-6-methylpyridine → 2-(3-(benzyloxy)-6-chloropyridin-2-yl)-4-fluoro-1H-pyrrolo[2,3-c]pyridine (1427034-48-7)

Guidance literature:

With copper(l) iodide; potassium carbonate; triphenylphosphine; In 1,4-dioxane; at 110 ℃; for 10h; Inert atmosphere;

Reference yield: 25.0%

2,2,2-trifluoro-N-(5-fluoro-4-iodopyridin-3-yl)acetamide (1427035-53-7) + C14H10ClNO (1427035-54-8) → 2-(3-(benzyloxy)-6-chloropyridin-2-yl)-4-fluoro-1H-pyrrolo[2,3-c]pyridine (1427034-48-7)

Guidance literature:

With copper(l) iodide; potassium carbonate; triphenylphosphine; In 1,4-dioxane; at 110 ℃; for 10h; Inert atmosphere;

Reference yield: 31.0%

2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide (1333340-17-2) + 2-(3-(benzyloxy)-6-chloropyridin-2-yl)-4-fluoro-1H-pyrrolo[2,3-c]pyridine (1427034-48-7) → 5-(5-(benzyloxy)-6-(4-fluoro-1H-pyrrolo[2,3-c]pyridin-2-yl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide (1427034-49-8)

Guidance literature:

With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; at 100 ℃; for 3h;

upstream raw materials:

2,2,2-trifluoro-N-(5-fluoro-4-iodopyridin-3-yl)acetamide

C₁₄H₁₀ClNO

Downstream raw materials:

5-(6-(4-fluoro-1H-pyrrolo[2,3-c]pyridin-2-yl)-5-hydroxypyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

5-(11-fluoro-6H-pyrido[2,3-c]pyrido[4',3': 4,5]pyrrolo[1,2-c][1,3]oxazin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

5-(5-(benzyloxy)-6-(4-fluoro-1H-pyrrolo[2,3-c]pyridin-2-yl)pyridin-2-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

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