O-acetyl-salicylic acid

Base Information

• Chemical Name: O-acetyl-salicylic acid
• CAS No.: 99512-66-0
• Molecular Formula: C₉H₈O₄
• Molecular Weight: 180.16
• Mol file: 99512-66-0.mol

Synonyms:O-acetyl-salicylic acid

Chemical Property of O-acetyl-salicylic acid

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of O-acetyl-salicylic acid

There total 7 articles about O-acetyl-salicylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Amino-6-acetylbenzoic acid (103440-81-9) → 3-Hydroxyacetophenone (121-71-1) + O-acetyl-salicylic acid (99512-66-0)

Guidance literature:

With sulfuric acid; sodium nitrite;

Reference yield:

2-acetyl-6-amino-benzoic acid methyl ester (179678-23-0) → O-acetyl-salicylic acid (99512-66-0) + methyl 1-hydroxy-6-acetylbenzoate (136192-85-3)

Guidance literature:

With sulfuric acid; sodium nitrite;

Reference yield:

2-acetyl-6-nitrobenzoic acid (13619-70-0) → O-acetyl-salicylic acid (99512-66-0)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanolic H₂SO₄

2: palladium/charcoal; ethanol; 2-methoxy-ethanol / Hydrogenation

3: aqueous H₂SO₄; NaNO₂

With palladium on activated charcoal; ethanol; 2-methoxy-ethanol; sulfuric acid; sodium nitrite;

upstream raw materials:

2-Amino-6-acetylbenzoic acid

2-acetyl-6-amino-benzoic acid methyl ester

2-acetyl-6-nitrobenzoic acid

2-acetyl-6-nitro-benzoic acid methyl ester

Downstream raw materials:

2-(Methoxycarbonyl)-3-methoxyacetophenone

pyriminobac-methyl

methyl 1-hydroxy-6-acetylbenzoate