benzyl 5-tert-butyl-3--L-alanyl>-2,3-dihydro-1,3,4-thiadiazole-2(R)-carboxylate

Base Information

• Chemical Name: benzyl 5-tert-butyl-3--L-alanyl>-2,3-dihydro-1,3,4-thiadiazole-2(R)-carboxylate
• CAS No.: 109683-69-4
• Molecular Formula: C₂₉H₃₇N₃O₅S
• Molecular Weight: 539.696

Synonyms:benzyl 5-tert-butyl-3--L-alanyl>-2,3-dihydro-1,3,4-thiadiazole-2(R)-carboxylate

Chemical Property of benzyl 5-tert-butyl-3--L-alanyl>-2,3-dihydro-1,3,4-thiadiazole-2(R)-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of benzyl 5-tert-butyl-3--L-alanyl>-2,3-dihydro-1,3,4-thiadiazole-2(R)-carboxylate

There total 2 articles about benzyl 5-tert-butyl-3--L-alanyl>-2,3-dihydro-1,3,4-thiadiazole-2(R)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,1-dimethylethanethioic acid hydrazide (93114-01-3) → benzyl 5-tert-butyl-3--L-alanyl>-2,3-dihydro-1,3,4-thiadiazole-2(R)-carboxylate (109683-69-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / ethanol / 16 h / Ambient temperature

2: 0.82 g / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CH₂Cl₂ / 16 h / Ambient temperature

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;

DOI:10.1021/jm00105a066

Reference yield:

benzylglyoxylate (52709-42-9) → benzyl 5-tert-butyl-3--L-alanyl>-2,3-dihydro-1,3,4-thiadiazole-2(R)-carboxylate (109683-69-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 84 percent / ethanol / 16 h / Ambient temperature

2: 0.82 g / 1-hydroxybenzotriazole, dicyclohexylcarbodiimide / CH₂Cl₂ / 16 h / Ambient temperature

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In ethanol; dichloromethane;

DOI:10.1021/jm00105a066

Reference yield: 45.0%

benzyl 5-tert-butyl-3--L-alanyl>-2,3-dihydro-1,3,4-thiadiazole-2(R)-carboxylate (109683-69-4) → benzyl 5-tert-butyl-3--L-alanyl>-2,3-dihydro-1,3,4-thiadiazole-2(S)-carboxylate (109718-93-6)

Guidance literature:

With pyrrolidine; 3 A molecular sieve; In acetonitrile; for 6h; Ambient temperature;

DOI:10.1021/jm00105a066

upstream raw materials:

1,1-dimethylethanethioic acid hydrazide

benzylglyoxylate

Downstream raw materials:

benzyl 5-tert-butyl-3--L-alanyl>-2,3-dihydro-1,3,4-thiadiazole-2(S)-carboxylate

utibapril

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