4-(5-(5-amino-6-isopropoxypicolinamido)-6-isopropoxypicolinamido)-3-isopropoxybenzoic acid

Base Information

Chemical Name:4-(5-(5-amino-6-isopropoxypicolinamido)-6-isopropoxypicolinamido)-3-isopropoxybenzoic acid
CAS No.:1373319-34-6
Molecular Formula:C₂₈H₃₃N₅O₇
Molecular Weight:551.599
Hs Code.:

Synonyms:4-(5-(5-amino-6-isopropoxypicolinamido)-6-isopropoxypicolinamido)-3-isopropoxybenzoic acid

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Chemical Property of 4-(5-(5-amino-6-isopropoxypicolinamido)-6-isopropoxypicolinamido)-3-isopropoxybenzoic acid

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Technology Process of 4-(5-(5-amino-6-isopropoxypicolinamido)-6-isopropoxypicolinamido)-3-isopropoxybenzoic acid

There total 12 articles about 4-(5-(5-amino-6-isopropoxypicolinamido)-6-isopropoxypicolinamido)-3-isopropoxybenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1373319-46-0
methyl 4-(5-(5-amino-6-isopropoxypicolinamido)-6-isopropoxypicolinamido)-3-isopropoxybenzoate

: 1373319-34-6
4-(5-(5-amino-6-isopropoxypicolinamido)-6-isopropoxypicolinamido)-3-isopropoxybenzoic acid

Guidance literature:: With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; Inert atmosphere;
DOI:10.1039/c2ob07125h

Reference yield:

: 16013-85-7,136901-10-5
2,6-dicholoro-3-nitropyridine

: 1373319-34-6
4-(5-(5-amino-6-isopropoxypicolinamido)-6-isopropoxypicolinamido)-3-isopropoxybenzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: toluene / 0.25 h / 0 °C

1.2: 16.25 h / 0 - 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 16 h / 120 °C / Inert atmosphere

3.1: potassium permanganate / water; acetone / 12 h / 20 °C

4.1: dichlorotriphenylphosphorane / chloroform / Reflux; Inert atmosphere

5.1: tin(II) chloride dihdyrate / ethyl acetate / 12 h / 50 °C / Inert atmosphere

6.1: water; sodium hydroxide / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

With potassium permanganate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; tin(II) chloride dihdyrate; water; sodium hydroxide; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; chloroform; water; ethyl acetate; acetone; toluene; 2.1: Stille coupling;
DOI:10.1039/c2ob07125h

Reference yield:

: 186413-80-9
2-isopropoxy-3-nitro-6-vinylpyridine

: 1373319-34-6
4-(5-(5-amino-6-isopropoxypicolinamido)-6-isopropoxypicolinamido)-3-isopropoxybenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium permanganate / water; acetone / 12 h / 20 °C

2: dichlorotriphenylphosphorane / chloroform / Reflux; Inert atmosphere

3: tin(II) chloride dihdyrate / ethyl acetate / 12 h / 50 °C / Inert atmosphere

4: water; sodium hydroxide / tetrahydrofuran; methanol / 20 °C / Inert atmosphere

With potassium permanganate; tin(II) chloride dihdyrate; water; sodium hydroxide; dichlorotriphenylphosphorane; In tetrahydrofuran; methanol; chloroform; water; ethyl acetate; acetone;
DOI:10.1039/c2ob07125h