3-(1-cyclohexyl-1-hydroxybenzyl)-8-methyl-1-oxa-2,8-diazaspiro[4,5]dec-2-ene

Base Information

Chemical Name:3-(1-cyclohexyl-1-hydroxybenzyl)-8-methyl-1-oxa-2,8-diazaspiro[4,5]dec-2-ene
CAS No.:392700-15-1
Molecular Formula:C₂₁H₃₀N₂O₂
Molecular Weight:342.481
Hs Code.:

Synonyms:3-(1-cyclohexyl-1-hydroxybenzyl)-8-methyl-1-oxa-2,8-diazaspiro[4,5]dec-2-ene

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Chemical Property of 3-(1-cyclohexyl-1-hydroxybenzyl)-8-methyl-1-oxa-2,8-diazaspiro[4,5]dec-2-ene

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Technology Process of 3-(1-cyclohexyl-1-hydroxybenzyl)-8-methyl-1-oxa-2,8-diazaspiro[4,5]dec-2-ene

There total 5 articles about 3-(1-cyclohexyl-1-hydroxybenzyl)-8-methyl-1-oxa-2,8-diazaspiro[4,5]dec-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 392700-13-9
3-benzoyl-8-methyl-1-oxa-2,8-diazaspiro[4,5]dec-2-ene

: 931-51-1
cyclohexylmagnesiumchloride

: 392700-15-1
3-(1-cyclohexyl-1-hydroxybenzyl)-8-methyl-1-oxa-2,8-diazaspiro[4,5]dec-2-ene

Guidance literature:: In tetrahydrofuran; at 20 ℃;

Reference yield:

: 392700-11-7
3-benzoyl-1-oxa-2,8-diazaspiro [4.5] dec-2-ene-8-carboxylic acid tert-butyl ester

: 392700-15-1
3-(1-cyclohexyl-1-hydroxybenzyl)-8-methyl-1-oxa-2,8-diazaspiro[4,5]dec-2-ene

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / CF₃COOH / CH₂Cl₂ / 3 h / 0 °C

2: 71 percent / formic acid / 4 h / Heating

3: 61 percent / tetrahydrofuran / 20 °C

With trifluoroacetic acid; In tetrahydrofuran; formic acid; dichloromethane;

Reference yield:

: 4937-87-5
N-hydroxy-2-oxo-2-phenylethanimidoyl chloride

: 392700-15-1
3-(1-cyclohexyl-1-hydroxybenzyl)-8-methyl-1-oxa-2,8-diazaspiro[4,5]dec-2-ene

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / NaHCO₃ / ethyl acetate / 20 °C

2: 81 percent / CF₃COOH / CH₂Cl₂ / 3 h / 0 °C

3: 71 percent / formic acid / 4 h / Heating

4: 61 percent / tetrahydrofuran / 20 °C

With sodium hydrogencarbonate; trifluoroacetic acid; In tetrahydrofuran; formic acid; dichloromethane; ethyl acetate;