4937-87-5

Basic information

• Product Name: Benzeneethanimidoyl chloride, N-hydroxy-alpha-oxo- (9CI)
• Synonyms: Benzeneethanimidoyl chloride, N-hydroxy-alpha-oxo- (9CI)
• CAS NO: 4937-87-5
• Molecular Formula: C₈H₆ClNO₂
• Molecular Weight: 183.59174
• Product Categories: ACETYLHALIDE
• Mol File: 4937-87-5.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 328.4°C at 760 mmHg
• Flash Point: 152.4°C
• Appearance: /
• Density: 1.29g/cm³
• Vapor Pressure: 7.64E-05mmHg at 25°C
• Refractive Index: 1.567
• CAS DataBase Reference: Benzeneethanimidoyl chloride, N-hydroxy-alpha-oxo- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzeneethanimidoyl chloride, N-hydroxy-alpha-oxo- (9CI)(4937-87-5)
• EPA Substance Registry System: Benzeneethanimidoyl chloride, N-hydroxy-alpha-oxo- (9CI)(4937-87-5)

Safety Data

• Hazardous Substances Data: 4937-87-5(Hazardous Substances Data)

Usage

InChI:InChI=1/C8H6ClNO2/c9-8(10-12)7(11)6-4-2-1-3-5-6/h1-5,12H

Upstream product

• 532-54-7 oxo-phenyl-acetaldehyde oxime 
• 541-42-4 i-propyl nitrite 
• 532-27-4 1-chloroacetophenone 
• 544-16-1 n-Butyl nitrite 
• 75-36-5 acetyl chloride 
• 614-21-1 2-nitroacetophenone 
• 98-86-2 acetophenone 
• 7647-01-0 hydrogenchloride 
• 110-46-3 isopentyl nitrite 
• 1074-12-0 phenylglyoxal hydrate 
• 5667-47-0 phenacyldimethylsulfonium bromide 
• 60-29-7 diethyl ether 
• 16735-23-2 3-hydroxy-1-oxo-1-phenylpropan-2-aminium chloride 
• 5468-37-1 2-aminoacetophenone hydrochloride 

Downstream Products

• 6635-54-7 3,4-dibenzoyl-1,2,5-oxadiazole-N-oxide 
• 69316-11-6 α-hydroximido-(2-benzoyl)acetonitrile 
• 65-85-0 benzoic acid 
• 17838-89-0 2-phenyl-glyoxylohydroxamic acid 
• 10242-38-3 2-hydroxyimino-2-phenyl-acetohydroximoyl chloride 
• 107535-24-0 aminohydroxyiminomethylphenylketone 
• 75768-43-3 Bis(O-benzoylbenzoylformaldoximino)furoxan 
• 7568-93-6 2-Amino-1-phenylethanol 
• 532-96-7 N-benzoyl-N'-phenylhydrazine 
• 3672-49-9 phenyl(5-phenyl-1,2-oxazol-3-yl)methanone 
• 95981-47-8 phenyl-((3ar,6ac)-3a,4,5,6a-tetrahydro-furo[3,2-d]isoxazol-3-yl)-methanone 
• 95981-48-9 phenyl-((3ar,6ac)-3a,4,6,6a-tetrahydro-furo[3,4-d]isoxazol-3-yl)-methanone 
• 7064-02-0 phenyl (5-phenyl-4,5-dihydroisoxazol-3-yl)methanone 
• 61879-97-8 phenyl-((3at,7at)-3a,4,7,7a-tetrahydro-4r,7c-methano-benzo[d]isoxazol-3-yl)-methanone 

Relevant articles and documents

Discovery of Hydroxyamidine Derivatives as Highly Potent, Selective Indoleamine-2,3-dioxygenase 1 Inhibitors

In this study, a series of novel hydroxyamidine derivatives were identified as potent and selective IDO1 inhibitors by structure-based drug design. Among them, compounds 13-15 and 18 exhibited favorable enzymatic and cellular activities. Compound 18 showed improved bioavailability in mouse, rat, and dog (F% = 44%, 58.8%, 102.1%, respectively). With reasonable in vivo pharmacokinetic properties, compound 18 was further evaluated in a transgenic MC38 xenograft mouse model. The combination of compound 18 with PD-1 monoclonal antibody showed a synergistic antitumor effect. These data indicated that compound 18 as a potential cancer immunotherapy agent should warrant further investigation.

Synthesis and characterization of s-triazine cored tripodal keto-oxime and its trinuclear complexes

2,4,6-Tris(4-hydroxybenzimino)-1,3,5-triazine (II) has been synthesized by the reaction of 1equiv. melamine (I) and 3equiv. 4-hydroxybenzaldehyde and characterized by means of elemental analysis, 1H NMR, Fourier transform-infrared spectroscopy, and liquid

CASPASE INHIBITORS CONTAINING DICARBONYLAMINO-ISOXAZOLINE

The present invention relates to a dicarbonylamino-isoxazoline derivative as an inhibitor against various caspases and a therapeutic composition for preventing inflammation and apoptosis comprising the same.