ethyl 3-(2-formylphenyl)-1-phenylsulfonyl-1H-indole-2-carboxylate

Base Information

• Chemical Name: ethyl 3-(2-formylphenyl)-1-phenylsulfonyl-1H-indole-2-carboxylate
• CAS No.: 1095343-12-6
• Molecular Formula: C₂₄H₁₉NO₅S
• Molecular Weight: 433.485
• Mol file: 1095343-12-6.mol

Synonyms:ethyl 3-(2-formylphenyl)-1-phenylsulfonyl-1H-indole-2-carboxylate

Chemical Property of ethyl 3-(2-formylphenyl)-1-phenylsulfonyl-1H-indole-2-carboxylate

Chemical Property:

Purity/Quality:

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Technology Process of ethyl 3-(2-formylphenyl)-1-phenylsulfonyl-1H-indole-2-carboxylate

There total 1 articles about ethyl 3-(2-formylphenyl)-1-phenylsulfonyl-1H-indole-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

2-formylbenzene boronic acid (40138-16-7) + ethyl 1-(benzenesulfonyl)-1H-3-iodoindole-2-carboxylate (153827-71-5) → ethyl 3-(2-formylphenyl)-1-phenylsulfonyl-1H-indole-2-carboxylate (1095343-12-6)

Guidance literature:

With 1,1'-bis(diphenylphosphino)ferrocene; palladium diacetate; cesium fluoride; In 1,4-dioxane; at 80 ℃; Inert atmosphere;

DOI:10.1002/ejoc.200800643

Reference yield: 96.0%

ethyl 3-(2-formylphenyl)-1-phenylsulfonyl-1H-indole-2-carboxylate (1095343-12-6) → 3-(2-formylphenyl)-1H-indole-2-carboxylic acid (953063-18-8)

Guidance literature:

ethyl 3-(2-formylphenyl)-1-phenylsulfonyl-1H-indole-2-carboxylate; With lithium hydroxide; water; In tetrahydrofuran; at 60 ℃; for 16h;

With hydrogenchloride; In tetrahydrofuran; water; at 0 ℃; pH=2 - 3;

DOI:10.1002/ejoc.200800643

upstream raw materials:

2-formylbenzene boronic acid

ethyl 1-(benzenesulfonyl)-1H-3-iodoindole-2-carboxylate

Downstream raw materials:

3-(2-formylphenyl)-1H-indole-2-carboxylic acid