1'-HYDROXYSAFROLE,2',3'-OXIDE

Base Information

• Chemical Name: 1'-HYDROXYSAFROLE,2',3'-OXIDE
• CAS No.: 59901-91-6
• Molecular Formula: C10H10O4
• Molecular Weight: 194.187
• Mol file: 59901-91-6.mol

Synonyms:(benzo[d][1,3]dioxol-5-yl)(oxiran-2-yl)methanol;Benzo[1,3]dioxol-5-yl-oxiranyl-methanol;1-(3,4-(methylenedioxy)phenyl)-2,3-epoxypropan-1-ol;

Chemical Property of 1'-HYDROXYSAFROLE,2',3'-OXIDE

Chemical Property:

• Vapor Pressure: 1.79E-05mmHg at 25°C
• Refractive Index: 1.5030 (estimate)
• Boiling Point: 349.2°C at 760 mmHg
• Flash Point: 165°C
• PSA: 51.22000
• Density: 1.47g/cm³
• LogP: 0.84750

Purity/Quality:

99% ^*data from raw suppliers

1'-HYDROXYSAFROLE,2',3'-OXIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1'-HYDROXYSAFROLE,2',3'-OXIDE

There total 3 articles about 1'-HYDROXYSAFROLE,2',3'-OXIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1'-hydroxysafrole (5208-87-7) → 3-(3,4-methylenedioxyphenyl)-3-hydroxy-1,2-epoxypropane (59901-91-6)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 0 - 20 ℃;

DOI:10.1021/jo971526d

Reference yield:

piperonal (120-57-0,30024-74-9) → 3-(3,4-methylenedioxyphenyl)-3-hydroxy-1,2-epoxypropane (59901-91-6)

Guidance literature:

Multi-step reaction with 2 steps

1: tetrahydrofuran / 5 h / 0 °C / Inert atmosphere

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 3 h / 0 °C / Inert atmosphere

With 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;

Reference yield:

piperonal (120-57-0,30024-74-9) → 3-(3,4-methylenedioxyphenyl)-3-hydroxy-1,2-epoxypropane (59901-91-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 89 percent / tetrahydrofuran / 2 h / 20 °C

2: 67 percent / vanadyl acetylacetonate; t-BuOOH / CH₂Cl₂ / 24 h

With tert.-butylhydroperoxide; vanadyl acetylacetonate; In tetrahydrofuran; dichloromethane; 1: Grignard reaction;

DOI:10.1016/j.steroids.2005.10.005

upstream raw materials:

1'-hydroxysafrole

piperonal

Downstream raw materials:

3-(benzo[1,3]dioxol-5-yl)prop-2-en-1-ol

(benzo[d][1,3]dioxol-5-yl)(oxiran-2-yl)methyl acetate

2-exo,6-exo-bis(3',4'-methylenedioxyphenyl)-3,7-dioxabicyclo[3.3.0]octane

(+/-)-piperitol methyl ether