Technology Process of Methyl 4-(2-tert-butylamino-1-hydroxyethyl)-7-hy- droxyindole-2-carboxylate hydrochloride
There total 9 articles about Methyl 4-(2-tert-butylamino-1-hydroxyethyl)-7-hy- droxyindole-2-carboxylate hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
Ambient temperature;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 79 percent / AlCl3, HCl / dioxane / 16 h / 5 - 10 °C
2: 82 percent / hydrogen / palladium on charcoal / Ambient temperature
With
hydrogenchloride; aluminium trichloride; hydrogen;
palladium on activated charcoal;
In
1,4-dioxane;
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 100 percent / KOEt / diethyl ether / 20 h / Heating
2: 61 percent / iron powder / acetic acid / 3 h / 80 - 90 °C
3: 95 percent / 2 N NaOH / tetrahydrofuran; methanol / 24 h / Ambient temperature
4: 68 percent / 6 N HCl / methanol / 3 h / Heating
5: 75 percent / hydrogen / Pd on carbon (10percent) / methanol; tetrahydrofuran / 12001 Torr
6: 79 percent / AlCl3, HCl / dioxane / 16 h / 5 - 10 °C
7: 82 percent / hydrogen / palladium on charcoal / Ambient temperature
With
hydrogenchloride; sodium hydroxide; aluminium trichloride; potassium ethoxide; hydrogen; iron;
palladium on activated charcoal;
In
tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; acetic acid;
