(+/-)-1'-<3-(3,4-dichlorophenyl)-4-methylaminobutyl>spiro

Base Information

Chemical Name:(+/-)-1'-<3-(3,4-dichlorophenyl)-4-methylaminobutyl>spiro
CAS No.:173943-90-3
Molecular Formula:C₂₃H₂₈Cl₂N₂O
Molecular Weight:419.394
Hs Code.:

(+/-)-1'-<3-(3,4-dichlorophenyl)-4-methylaminobutyl>spiro<isobenzofuran-1(3H),4'-piperidine>

Synonyms:(+/-)-1'-<3-(3,4-dichlorophenyl)-4-methylaminobutyl>spiro

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Chemical Property of (+/-)-1'-<3-(3,4-dichlorophenyl)-4-methylaminobutyl>spiro

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Technology Process of (+/-)-1'-<3-(3,4-dichlorophenyl)-4-methylaminobutyl>spiro

There total 6 articles about (+/-)-1'-<3-(3,4-dichlorophenyl)-4-methylaminobutyl>spiro which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 173943-89-0
tert-butyl (+/-)-N-[2-(3,4-dichlorophenyl)-4-(spiro[isobenzofuran-1(3H),4'-piperidine]-1'-yl)butyl]-N-methylcarbamate

: 173943-90-3
(+/-)-1'-<3-(3,4-dichlorophenyl)-4-methylaminobutyl>spiro

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; for 1h;
DOI:10.1248/cpb.46.242

Reference yield:

: 152298-54-9,736905-09-2,786611-77-6
N-[2-(S)-(3,4-dichlorophenyl)-4-hydroxybutyl]-N-methylamine

: 173943-90-3
(+/-)-1'-<3-(3,4-dichlorophenyl)-4-methylaminobutyl>spiro

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / dioxane / 0.5 h / 60 °C

2: Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

3: Et₃N / dimethylformamide / 70 °C

4: 100 percent / TFA / CH₂Cl₂ / 1 h / 0 - 20 °C

With triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.242

Reference yield:

: 142001-75-0
tert-Butyl N-methyl-N-[2-(3,4-dichlorophenyl)-4-hydroxybutyl]carbamate

: 173943-90-3
(+/-)-1'-<3-(3,4-dichlorophenyl)-4-methylaminobutyl>spiro

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 2 h / Ambient temperature

2: Et₃N / dimethylformamide / 70 °C

3: 100 percent / TFA / CH₂Cl₂ / 1 h / 0 - 20 °C

With triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.242