(1S,4S,5S)-4-(2'-bromophenyl)-5-(tert-butyidimethylsiloxymethyl)-3-phenyl-2-oxa-3-azabicyclo[3.3.0]octane

Base Information

Chemical Name:(1S,4S,5S)-4-(2'-bromophenyl)-5-(tert-butyidimethylsiloxymethyl)-3-phenyl-2-oxa-3-azabicyclo[3.3.0]octane
CAS No.:646054-22-0
Molecular Formula:C₂₅H₃₄BrNO₂Si
Molecular Weight:488.54
Hs Code.:

Synonyms:(1S,4S,5S)-4-(2'-bromophenyl)-5-(tert-butyidimethylsiloxymethyl)-3-phenyl-2-oxa-3-azabicyclo[3.3.0]octane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,4S,5S)-4-(2'-bromophenyl)-5-(tert-butyidimethylsiloxymethyl)-3-phenyl-2-oxa-3-azabicyclo[3.3.0]octane

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Technology Process of (1S,4S,5S)-4-(2'-bromophenyl)-5-(tert-butyidimethylsiloxymethyl)-3-phenyl-2-oxa-3-azabicyclo[3.3.0]octane

There total 1 articles about (1S,4S,5S)-4-(2'-bromophenyl)-5-(tert-butyidimethylsiloxymethyl)-3-phenyl-2-oxa-3-azabicyclo[3.3.0]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6140-65-4
1-cyclopentene-1-carboxaldehyde

: 18162-48-6
tert-butyldimethylsilyl chloride

: N-(2-bromobenzylidene)phenylamine-N-oxide

: (1R,4R,5R)-4-(2'-bromophenyl)-5-(tert-butyidimethylsiloxymethyl)-3-phenyl-2-oxa-3-azabicyclo[3.3.0]octane

: 646054-22-0
(1S,4S,5S)-4-(2'-bromophenyl)-5-(tert-butyidimethylsiloxymethyl)-3-phenyl-2-oxa-3-azabicyclo[3.3.0]octane

Guidance literature:: 1-cyclopentene-1-carboxaldehyde; N-(2-bromobenzylidene)phenylamine-N-oxide; chiral 3-oxobutylideneaminatocobalt(III); In dichloromethane; at -40 ℃; for 96h;

With sodium tetrahydroborate; In ethanol; dichloromethane; at -40 ℃; for 1h;

tert-butyldimethylsilyl chloride; With 1H-imidazole; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Title compound not separated from byproducts;
DOI:10.1246/bcsj.76.2197

Reference yield:

: 646054-22-0
(1S,4S,5S)-4-(2'-bromophenyl)-5-(tert-butyidimethylsiloxymethyl)-3-phenyl-2-oxa-3-azabicyclo[3.3.0]octane

: 3a-(tert-butyl-dimethyl-silanyloxymethyl)-2,3-diphenyl-hexahydro-cyclopenta[d]isoxazole

Guidance literature:: (1S,4S,5S)-4-(2'-bromophenyl)-5-(tert-butyidimethylsiloxymethyl)-3-phenyl-2-oxa-3-azabicyclo[3.3.0]octane; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.0833333h;

With water; In tetrahydrofuran; hexane; at -78 - 20 ℃;
DOI:10.1246/bcsj.76.2197