3-[3-(4'-fluoro-biphenyl-4-yl)-1-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-acrylic acid

Base Information

Chemical Name:3-[3-(4'-fluoro-biphenyl-4-yl)-1-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-acrylic acid
CAS No.:1026504-64-2
Molecular Formula:C₂₅H₁₆F₄N₂O₂
Molecular Weight:452.408
Hs Code.:

3-[3-(4'-fluoro-biphenyl-4-yl)-1-(3-trifluoromethyl-phenyl)-1<i>H</i>-pyrazol-4-yl]-acrylic acid

Synonyms:3-[3-(4'-fluoro-biphenyl-4-yl)-1-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-acrylic acid

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Chemical Property of 3-[3-(4'-fluoro-biphenyl-4-yl)-1-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-acrylic acid

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Technology Process of 3-[3-(4'-fluoro-biphenyl-4-yl)-1-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-acrylic acid

There total 4 articles about 3-[3-(4'-fluoro-biphenyl-4-yl)-1-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 141-82-2
malonic acid

: 1026852-02-7
3-(4'-fluoro-biphenyl-4-yl)-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carbaldehyde

: 1026504-64-2
3-[3-(4'-fluoro-biphenyl-4-yl)-1-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-acrylic acid

Guidance literature:: With piperidine; pyridine; at 90 ℃; for 12h;
DOI:10.1021/jm010032c

Reference yield:

: 720-74-1
4'-fluoro-4-acetyl-1,1'-biphenyl

: 1026504-64-2
3-[3-(4'-fluoro-biphenyl-4-yl)-1-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. AcOH / 15 h

2.1: POCl₃ / 0.5 h / 0 °C

2.2: 15 h

3.1: pyridine; piperidine / 12 h / 90 °C

With piperidine; pyridine; acetic acid; trichlorophosphate; 2.2: Vilsmeier-Haack reaction;
DOI:10.1021/jm010032c

Reference yield:

: 368-78-5
3-(trifluoromethyl)phenylhydrazine

: 1026504-64-2
3-[3-(4'-fluoro-biphenyl-4-yl)-1-(3-trifluoromethyl-phenyl)-1H-pyrazol-4-yl]-acrylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. AcOH / 15 h

2.1: POCl₃ / 0.5 h / 0 °C

2.2: 15 h

3.1: pyridine; piperidine / 12 h / 90 °C

With piperidine; pyridine; acetic acid; trichlorophosphate; 2.2: Vilsmeier-Haack reaction;
DOI:10.1021/jm010032c