1-(4'-Fluoro-biphenyl-4-yl)-ethanone

Base Information

• Chemical Name: 1-(4'-Fluoro-biphenyl-4-yl)-ethanone
• CAS No.: 720-74-1
• Molecular Formula: C14H11FO
• Molecular Weight: 214.239
• Hs Code.: 2914700090
• DSSTox Substance ID: DTXSID70345930
• Nikkaji Number: J132.622H
• Wikidata: Q82118730
• Mol file: 720-74-1.mol

Synonyms:720-74-1;1-(4'-Fluoro-biphenyl-4-yl)-ethanone;1-[4-(4-fluorophenyl)phenyl]ethanone;1-(4'-fluorobiphenyl-4-yl)ethanone;1-(4'-Fluoro[1,1'-biphenyl]-4-yl)ethanone;Ethanone, 1-(4'-fluoro[1,1'-biphenyl]-4-yl)-;1-(4'-fluoro[1,1-biphenyl]-4-yl)ethanone;1-(4'-fluoro-biphenyl-4-yl)ethanone;1-(4'-Fluoro-[1,1'-biphenyl]-4-yl)ethan-1-one;4'-fluoro-4-acetylbiphenyl;4-acetyl-4'-fluorobiphenyl;SCHEMBL4448294;DTXSID70345930;4-acetyl-4'-fluoro-1,1'-biphenyl;MFCD04039227;AKOS004114080;BB 0222540;CS-0331249;FT-0710182;E89732;1-(4'-Fluoro-[1,1'-biphenyl]-4-yl)ethanone;1-(4'-Fluoro[1,1'-biphenyl]-4-yl)ethanone #;A1-10764

Chemical Property of 1-(4'-Fluoro-biphenyl-4-yl)-ethanone

Chemical Property:

• Boiling Point: 324oC at 760 mmHg
• Flash Point: 133.7oC
• PSA: 17.07000
• Density: 1.124g/cm3
• LogP: 3.69530
• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 214.079393132
• Heavy Atom Count: 16
• Complexity: 235

Purity/Quality:

98% ^*data from raw suppliers

1-(4'-Fluoro-biphenyl-4-yl)ethanone ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC=C(C=C1)C2=CC=C(C=C2)F

Technology Process of 1-(4'-Fluoro-biphenyl-4-yl)-ethanone

There total 1 articles about 1-(4'-Fluoro-biphenyl-4-yl)-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-fluoroboronic acid (1765-93-1) + p-bromobenzoylmethylenetriphenylphosphorane (1777-57-7) → 4'-fluoro-4-acetyl-1,1'-biphenyl (720-74-1) + 4-(p-fluorophenyl)benzoylmethylidenetriphenylphosphorane (254453-88-8)

Guidance literature:

With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; at 75 ℃; for 5h;

DOI:10.1039/b202745n

Reference yield: 82.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-(4-chlorophenyl)-1,2,3,6-tetrahydropyridine (30005-58-4) + 4'-fluoro-4-acetyl-1,1'-biphenyl (720-74-1) → 3-[4-(4-Chloro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-1-(4'-fluoro-biphenyl-4-yl)-propan-1-one; hydrochloride

Guidance literature:

With hydrogenchloride; In ethanol; for 24h; Heating;

DOI:10.1016/0223-5234(94)90059-0

Reference yield: 81.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-(p-fluorophenyl)-1,2,3,6-tetrahydropyridine (1978-59-2) + 4'-fluoro-4-acetyl-1,1'-biphenyl (720-74-1) → 1-(4'-Fluoro-biphenyl-4-yl)-3-[4-(4-fluoro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-propan-1-one; hydrochloride

Guidance literature:

With hydrogenchloride; In ethanol; for 24h; Heating;

DOI:10.1016/0223-5234(94)90059-0

upstream raw materials:

4-fluoroboronic acid

p-bromobenzoylmethylenetriphenylphosphorane

Downstream raw materials:

1-(4'-decylbiphenyl-4-yl)-3-(4'-fluorobiphenyl-4-yl)propane-1,3-dione

4'-fluoro-biphenyl-4-carboxylic acid

N-[1-(4'-fluoro-biphenyl-4-yl)-ethylidene]-N'-(3-trifluoromethyl-phenyl)-hydrazine

3-(4'-fluoro-biphenyl-4-yl)-1-(3-trifluoromethyl-phenyl)-1H-pyrazole-4-carbaldehyde

Refernces