(S)-2-(2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-yl)-4-phenyl-4,5-dihydrooxazole

Base Information

Chemical Name:(S)-2-(2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-yl)-4-phenyl-4,5-dihydrooxazole
CAS No.:1198617-05-8
Molecular Formula:C₄₉H₅₈NO₂P
Molecular Weight:723.979
Hs Code.:

Synonyms:(S)-2-(2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-yl)-4-phenyl-4,5-dihydrooxazole

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Chemical Property of (S)-2-(2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-yl)-4-phenyl-4,5-dihydrooxazole

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Technology Process of (S)-2-(2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-yl)-4-phenyl-4,5-dihydrooxazole

There total 4 articles about (S)-2-(2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-yl)-4-phenyl-4,5-dihydrooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 1198617-01-4
(S)-2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)-N-(2-hydroxy-1-phenylethyl)biphenyl-2-carboxamide

: 1198617-05-8
(S)-2-(2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-yl)-4-phenyl-4,5-dihydrooxazole

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.tet.2009.09.053

Reference yield:

: 22749-43-5
p-chlorodibenzo[c.e][1,2]oxaphosphorine

: 1198617-05-8
(S)-2-(2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-yl)-4-phenyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 5 steps

1.1: iodine; magnesium / 2 h / 50 °C / Inert atmosphere; Reflux

1.2: 25 °C / Inert atmosphere; Reflux

1.3: 0 °C / Inert atmosphere

2.1: dihydrogen peroxide / dichloromethane; water / 0 - 20 °C

3.1: pyridine; dmap / dichloromethane / 0 °C / Reflux

4.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 18 h / 110 °C

5.1: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; 1,3-bis-(diphenylphosphino)propane; dihydrogen peroxide; iodine; palladium diacetate; magnesium; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; dimethyl sulfoxide;
DOI:10.1007/s11426-010-4172-z

Reference yield:

: 1266398-33-7
2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-ol

: 1198617-05-8
(S)-2-(2'-(bis(3,5-di-tert-butylphenyl)phosphoryl)biphenyl-2-yl)-4-phenyl-4,5-dihydrooxazole

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine; dmap / dichloromethane / 0 °C / Reflux

2: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 18 h / 110 °C

3: methanesulfonyl chloride; triethylamine / dichloromethane / 0 - 20 °C / Inert atmosphere

With pyridine; dmap; 1,3-bis-(diphenylphosphino)propane; palladium diacetate; methanesulfonyl chloride; triethylamine; N-ethyl-N,N-diisopropylamine; In dichloromethane; dimethyl sulfoxide;
DOI:10.1007/s11426-010-4172-z