benzyl (3R,6S)-[N-(p-methoxybenzyl)-6-methyl-2,5-dioxo-1,4-morpholin-3-yl]acetate

Base Information

Chemical Name:benzyl (3R,6S)-[N-(p-methoxybenzyl)-6-methyl-2,5-dioxo-1,4-morpholin-3-yl]acetate
CAS No.:833489-48-8
Molecular Formula:C₂₂H₂₃NO₆
Molecular Weight:397.428
Hs Code.:

Synonyms:benzyl (3R,6S)-[N-(p-methoxybenzyl)-6-methyl-2,5-dioxo-1,4-morpholin-3-yl]acetate

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Chemical Property of benzyl (3R,6S)-[N-(p-methoxybenzyl)-6-methyl-2,5-dioxo-1,4-morpholin-3-yl]acetate

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Technology Process of benzyl (3R,6S)-[N-(p-methoxybenzyl)-6-methyl-2,5-dioxo-1,4-morpholin-3-yl]acetate

There total 3 articles about benzyl (3R,6S)-[N-(p-methoxybenzyl)-6-methyl-2,5-dioxo-1,4-morpholin-3-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 5437-45-6
Benzyl bromoacetate

: 833489-47-7
(6S)-N-(p-methoxybenzyl)-6-methyl-1,4-morpholine-2,5-dione

: 833489-48-8
benzyl (3R,6S)-[N-(p-methoxybenzyl)-6-methyl-2,5-dioxo-1,4-morpholin-3-yl]acetate

Guidance literature:: (6S)-N-(p-methoxybenzyl)-6-methyl-1,4-morpholine-2,5-dione; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

Benzyl bromoacetate; In tetrahydrofuran;
DOI:10.1007/s00706-004-0195-5

Reference yield:

: 60857-16-1
N-(4-methoxybenzyl)glycine ethyl ester

: 833489-48-8
benzyl (3R,6S)-[N-(p-methoxybenzyl)-6-methyl-2,5-dioxo-1,4-morpholin-3-yl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: Et₃N / CH₂Cl₂ / 0 - 20 °C

1.2: aq. HCl / CH₂Cl₂

1.3: 80 percent / NaOH / ethanol; H₂O

2.1: LiHMDS / tetrahydrofuran / 1 h / -78 °C

2.2: 85 percent / tetrahydrofuran

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1007/s00706-004-0195-5

Reference yield:

: 2393-23-9
4-methoxy-benzylamine

: 833489-48-8
benzyl (3R,6S)-[N-(p-methoxybenzyl)-6-methyl-2,5-dioxo-1,4-morpholin-3-yl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 85 percent / Et₃N / CH₂Cl₂ / 3 h / 20 °C

2.1: Et₃N / CH₂Cl₂ / 0 - 20 °C

2.2: aq. HCl / CH₂Cl₂

2.3: 80 percent / NaOH / ethanol; H₂O

3.1: LiHMDS / tetrahydrofuran / 1 h / -78 °C

3.2: 85 percent / tetrahydrofuran

With triethylamine; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane;
DOI:10.1007/s00706-004-0195-5