2(3H)-Furanone,4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(3,4,5-trimethoxyphenyl)methyl]-,(3R,4R)-

Base Information

Chemical Name:2(3H)-Furanone,4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(3,4,5-trimethoxyphenyl)methyl]-,(3R,4R)-
CAS No.:10516-73-1
Molecular Formula:C23H28 O7
Molecular Weight:416.46
Hs Code.:2932209090

Synonyms:2(3H)-Furanone,4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(3,4,5-trimethoxyphenyl)methyl]-,(3R-trans)-; 2(3H)-Furanone, dihydro-3-(3,4,5-trimethoxybenzyl)-4-veratryl-,(-)-trans- (8CI); Thujaplicatin, tri-O-methyl- (7CI); Thujaplicatin,tri-O-methyl-, (-)-trans-

Suppliers and Price of 2(3H)-Furanone,4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(3,4,5-trimethoxyphenyl)methyl]-,(3R,4R)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2(3H)-Furanone,4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(3,4,5-trimethoxyphenyl)methyl]-,(3R,4R)-

Chemical Property:

PSA：72.45000
LogP:3.30400

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2(3H)-Furanone,4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(3,4,5-trimethoxyphenyl)methyl]-,(3R,4R)-

There total 13 articles about 2(3H)-Furanone,4-[(3,4-dimethoxyphenyl)methyl]dihydro-3-[(3,4,5-trimethoxyphenyl)methyl]-,(3R,4R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 21852-50-6
3,4,5-trimethoxybenzyl bromide

: 108102-77-8
(R)-4-(3,4-dimethoxybenzyl)dihydrofuran-2(3H)-one

: 10516-73-1
(-)-Thujaplicatin trimethyl ether

Guidance literature:: (R)-4-(3,4-dimethoxybenzyl)dihydrofuran-2(3H)-one; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 1h;

3,4,5-trimethoxybenzyl bromide; In tetrahydrofuran; for 2h;
DOI:10.1002/anie.201904102

Reference yield: 31.0%

: 17301-91-6,40456-50-6,61091-56-3,72690-16-5,96745-44-7,119066-80-7,128049-89-8,139560-31-9
(3R*,4R*)-3-(3,4,5-trimethoxybenzyl)-4-(3,4-methylenedioxybenzyl)-4,5-dihydro-2(3H)-furanone

: 6512-69-2,6512-71-6,10516-73-1,65700-61-0,111768-69-5,118626-39-4
di-O-methylthujaplicantin methyl ether

Guidance literature:: With boron tribromide; In dichloromethane; at -78 ℃; for 0.5h;

Reference yield:

: 120-57-0,30024-74-9
piperonal

: 6512-69-2,6512-71-6,10516-73-1,65700-61-0,111768-69-5,118626-39-4
di-O-methylthujaplicantin methyl ether

Guidance literature:: Multi-step reaction with 6 steps

1: 40 percent / dimethylformamide; tetrahydrofuran / 240 h / Ambient temperature

2: 99 percent / 20percent Pd/C, H₂ / ethyl acetate

3: 1.) potassium hydroxide, 2.) sodium borohydride, calcium chloride / 1.) ethanol, 2.) ethanol, a) -23 deg C, 1 h, b.) room temp., overnight

4: 1.) butyllitium, diisopropylamine / 1.) hexane, THF, -78 deg C, 30 min, 2.) hexane, THF, 2 h

5: 1.) trifluoroacetic acid, triethylamine, 2.) H₂ / 10percent Pd/C / 1.) ethyl acetate, 0 deg C, 2.) ethyl acetate, RT, 1 atm

6: 31 percent / boron tribromide / CH₂Cl₂ / 0.5 h / -78 °C

With potassium hydroxide; sodium tetrahydroborate; palladium on activated charcoal; n-butyllithium; hydrogen; boron tribromide; triethylamine; diisopropylamine; trifluoroacetic acid; calcium chloride; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;