[(3R,4S)-1-(5-{(S)-1-[1-(butane-1-sulfonyl)-piperidin-4-yl]ethoxy}pyrimidin-2-yl)-4-(2,4,5-trifluoro-phenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

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Chemical Name:[(3R,4S)-1-(5-{(S)-1-[1-(butane-1-sulfonyl)-piperidin-4-yl]ethoxy}pyrimidin-2-yl)-4-(2,4,5-trifluoro-phenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester
CAS No.:1351343-23-1
Molecular Formula:C₃₀H₄₂F₃N₅O₅S
Molecular Weight:641.755
Hs Code.:

Synonyms:[(3R,4S)-1-(5-{(S)-1-[1-(butane-1-sulfonyl)-piperidin-4-yl]ethoxy}pyrimidin-2-yl)-4-(2,4,5-trifluoro-phenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

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Chemical Property of [(3R,4S)-1-(5-{(S)-1-[1-(butane-1-sulfonyl)-piperidin-4-yl]ethoxy}pyrimidin-2-yl)-4-(2,4,5-trifluoro-phenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

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Technology Process of [(3R,4S)-1-(5-{(S)-1-[1-(butane-1-sulfonyl)-piperidin-4-yl]ethoxy}pyrimidin-2-yl)-4-(2,4,5-trifluoro-phenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

There total 12 articles about [(3R,4S)-1-(5-{(S)-1-[1-(butane-1-sulfonyl)-piperidin-4-yl]ethoxy}pyrimidin-2-yl)-4-(2,4,5-trifluoro-phenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2386-60-9
perfluoro-1-butanesulfonyl fluoride

: 1351343-21-9
[(3R,4S)-1-[5-((S)-1-piperidin-4-yl-ethoxy)pyrimidin-2-yl]-4-(2,4,5-trifluoro-phenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

: 1351343-23-1
[(3R,4S)-1-(5-{(S)-1-[1-(butane-1-sulfonyl)-piperidin-4-yl]ethoxy}pyrimidin-2-yl)-4-(2,4,5-trifluoro-phenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1122-54-9
methyl (4-pyridyl) ketone

: 1351343-23-1
[(3R,4S)-1-(5-{(S)-1-[1-(butane-1-sulfonyl)-piperidin-4-yl]ethoxy}pyrimidin-2-yl)-4-(2,4,5-trifluoro-phenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: dimethylsulfide borane complex; Trimethyl borate; (S)-diphenylprolinol / tetrahydrofuran / 0 - 20 °C

2.1: hydrogen / platinum oxide / methanol / 18 h / 38002.6 Torr / Inert atmosphere

3.1: sodium carbonate / dichloromethane; water / 16 h / 20 °C

4.1: triethylamine / dichloromethane / 0.5 h / 0 °C

4.2: 4 h / 0 - 20 °C

5.1: cesium fluoride / ISOPROPYLAMIDE / 168 h / 60 °C

6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 109 h / 90 - 140 °C / Inert atmosphere

7.1: hydrogen / palladium 10% on activated carbon / ethanol / 5 h / 20 - 50 °C

8.1: triethylamine / dichloromethane / 16 h / 20 °C

With Trimethyl borate; (S)-diphenylprolinol; dimethylsulfide borane complex; hydrogen; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; cesium fluoride; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; water; dimethyl sulfoxide;

Reference yield:

: 27854-88-2,42732-22-9
(R)-1-(4-pyridinyl)ethanol

: 1351343-23-1
[(3R,4S)-1-(5-{(S)-1-[1-(butane-1-sulfonyl)-piperidin-4-yl]ethoxy}pyrimidin-2-yl)-4-(2,4,5-trifluoro-phenyl)pyrrolidin-3-yl]carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: hydrogen / platinum oxide / methanol / 18 h / 38002.6 Torr / Inert atmosphere

2.1: sodium carbonate / dichloromethane; water / 16 h / 20 °C

3.1: triethylamine / dichloromethane / 0.5 h / 0 °C

3.2: 4 h / 0 - 20 °C

4.1: cesium fluoride / ISOPROPYLAMIDE / 168 h / 60 °C

5.1: 1,8-diazabicyclo[5.4.0]undec-7-ene / dimethyl sulfoxide / 109 h / 90 - 140 °C / Inert atmosphere

6.1: hydrogen / palladium 10% on activated carbon / ethanol / 5 h / 20 - 50 °C

7.1: triethylamine / dichloromethane / 16 h / 20 °C

With hydrogen; sodium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; cesium fluoride; palladium 10% on activated carbon; In methanol; ethanol; dichloromethane; ISOPROPYLAMIDE; water; dimethyl sulfoxide;