t-butyl O-[2-(2-(2-(N-t-butoxycarbonyl)-2-aminoethoxy)ethoxy)ethyl]-meta-amino-N-[3-(trifluoromethyl)phenylsulfonyl]-L-tyrosinate

Base Information

Chemical Name:t-butyl O-[2-(2-(2-(N-t-butoxycarbonyl)-2-aminoethoxy)ethoxy)ethyl]-meta-amino-N-[3-(trifluoromethyl)phenylsulfonyl]-L-tyrosinate
CAS No.:798567-51-8
Molecular Formula:C₃₁H₄₄F₃N₃O₉S
Molecular Weight:691.766
Hs Code.:

Synonyms:t-butyl O-[2-(2-(2-(N-t-butoxycarbonyl)-2-aminoethoxy)ethoxy)ethyl]-meta-amino-N-[3-(trifluoromethyl)phenylsulfonyl]-L-tyrosinate

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Chemical Property of t-butyl O-[2-(2-(2-(N-t-butoxycarbonyl)-2-aminoethoxy)ethoxy)ethyl]-meta-amino-N-[3-(trifluoromethyl)phenylsulfonyl]-L-tyrosinate

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Technology Process of t-butyl O-[2-(2-(2-(N-t-butoxycarbonyl)-2-aminoethoxy)ethoxy)ethyl]-meta-amino-N-[3-(trifluoromethyl)phenylsulfonyl]-L-tyrosinate

There total 3 articles about t-butyl O-[2-(2-(2-(N-t-butoxycarbonyl)-2-aminoethoxy)ethoxy)ethyl]-meta-amino-N-[3-(trifluoromethyl)phenylsulfonyl]-L-tyrosinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 777-44-6
3-(Trifluoromethyl)benzenesulfonyl chloride

: 798567-51-8
t-butyl O-[2-(2-(2-(N-t-butoxycarbonyl)-2-aminoethoxy)ethoxy)ethyl]-meta-amino-N-[3-(trifluoromethyl)phenylsulfonyl]-L-tyrosinate

Guidance literature:: Multi-step reaction with 4 steps

1: 48 percent / pyridine / CH₂Cl₂ / 5 h / 20 °C

2: 95 percent / acetic acid; nitric acid / 16 - 20 °C

3: 60 percent / DIAD; bis(diphenylphosphino)ethane / tetrahydrofuran / 20 h / 20 °C

4: H₂ / PtO₂ / ethyl acetate / 18 h / 20 °C / 2068.59 Torr

With pyridine; di-isopropyl azodicarboxylate; hydrogen; nitric acid; acetic acid; 1,2-bis-(diphenylphosphino)ethane; platinum(IV) oxide; In tetrahydrofuran; dichloromethane; ethyl acetate; 3: Mitsunobu reaction;
DOI:10.1016/j.bmc.2004.07.055

Reference yield:

: 432515-20-3
(S)-t-butyl 3-(4-hydroxyphenyl)-2-(3-trifluoromethylbenzenesulfonylamino)propionate

: 798567-51-8
t-butyl O-[2-(2-(2-(N-t-butoxycarbonyl)-2-aminoethoxy)ethoxy)ethyl]-meta-amino-N-[3-(trifluoromethyl)phenylsulfonyl]-L-tyrosinate

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / acetic acid; nitric acid / 16 - 20 °C

2: 60 percent / DIAD; bis(diphenylphosphino)ethane / tetrahydrofuran / 20 h / 20 °C

3: H₂ / PtO₂ / ethyl acetate / 18 h / 20 °C / 2068.59 Torr

With di-isopropyl azodicarboxylate; hydrogen; nitric acid; acetic acid; 1,2-bis-(diphenylphosphino)ethane; platinum(IV) oxide; In tetrahydrofuran; ethyl acetate; 2: Mitsunobu reaction;
DOI:10.1016/j.bmc.2004.07.055

Reference yield:

: 432515-23-6
t-butyl (S)-3-(4-hydroxy-3-nitrophenyl)-2-(3-trifluoromethyl-1-benzenesulfonylamino)-propionate

: 798567-51-8
t-butyl O-[2-(2-(2-(N-t-butoxycarbonyl)-2-aminoethoxy)ethoxy)ethyl]-meta-amino-N-[3-(trifluoromethyl)phenylsulfonyl]-L-tyrosinate

Guidance literature:: Multi-step reaction with 2 steps

1: 60 percent / DIAD; bis(diphenylphosphino)ethane / tetrahydrofuran / 20 h / 20 °C

2: H₂ / PtO₂ / ethyl acetate / 18 h / 20 °C / 2068.59 Torr

With di-isopropyl azodicarboxylate; hydrogen; 1,2-bis-(diphenylphosphino)ethane; platinum(IV) oxide; In tetrahydrofuran; ethyl acetate; 1: Mitsunobu reaction;
DOI:10.1016/j.bmc.2004.07.055