N,N-dimethyl-1,2-diphenylethanamine

Base Information

• Chemical Name: N,N-dimethyl-1,2-diphenylethanamine
• CAS No.: 6319-84-2
• Molecular Formula: C16H19N
• Molecular Weight: 225.334
• Hs Code.: 2921499090
• NSC Number: 31924
• UNII: 3ZTM81JPDB
• DSSTox Substance ID: DTXSID10859960
• Nikkaji Number: J41.165E,J93.014H
• Wikidata: Q27258268
• Mol file: 6319-84-2.mol

Synonyms:NSC 31924;6319-84-2;Lefetamine, (+/-)-;UNII-3ZTM81JPDB;3ZTM81JPDB;BRN 2102635;dl-N,N-Dimethyl-1,2-diphenyl-ethylamine;NSC-31924;ETHYLAMINE, N,N-DIMETHYL-1,2-DIPHENYL-, (+-)-;N,N-dimethyl-1,2-diphenylethanamine;4-12-00-03313 (Beilstein Handbook Reference);l-spa;(+/-)-lefetamine;SCHEMBL1650099;DTXSID10859960;1,2-diphenyl-ethyl-dimethyl-amine;NSC31924;N,N-dimethyl-1,2-diphenylethylamine;CS-6693;LS-68099;N,N-Dimethyl-1,2-diphenylethan-1-amine;(?)-N,N-Dimethyl-1,2-diphenylethanamine;HY-101806;N,N-DIMETHYL-1,2-DI(PHENYL)ETHANAMINE;Q27258268;BENZENEETHANAMINE, N,N-DIMETHYL-.ALPHA.-PHENYL-

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Chemical Property of N,N-dimethyl-1,2-diphenylethanamine

Chemical Property:

• PSA: 3.24000
• LogP: 3.53200
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 225.151749610
• Heavy Atom Count: 17
• Complexity: 200

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C(CC1=CC=CC=C1)C2=CC=CC=C2

Technology Process of N,N-dimethyl-1,2-diphenylethanamine

There total 17 articles about N,N-dimethyl-1,2-diphenylethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

→ bibenzyl-α-yl-dimethyl-amine (6319-84-2)

Guidance literature:

In ethanol; Heating; overnight;

DOI:10.1016/S0040-4020(98)00783-2

Reference yield: 89.0%

N,N-dimethylbenzamide (611-74-5) + benzylmagnesium chloride (6921-34-2) → bibenzyl-α-yl-dimethyl-amine (6319-84-2)

Guidance literature:

N,N-dimethylbenzamide; With bis(triphenylphosphine)carbonyliridium(I) chloride; 1,1,3,3-Tetramethyldisiloxane; In dichloromethane; at 20 ℃; for 0.333333h;

benzylmagnesium chloride; at -78 - 20 ℃; for 4h; Solvent; Catalytic behavior;

DOI:10.1039/c7sc03613b

Reference yield: 58.0%

(α-butoxy-benzyl)-dimethyl-amine (20599-29-5) + benzyl chloride (100-44-7) → bibenzyl-α-yl-dimethyl-amine (6319-84-2)

Guidance literature:

(α-butoxy-benzyl)-dimethyl-amine; With naphthalene; lithium; In tetrahydrofuran; at -20 ℃; for 5h;

benzyl chloride; In tetrahydrofuran; at -20 ℃; for 0.166667h;

DOI:10.1016/S0040-4020(00)00303-3

upstream raw materials:

diethyl ether

N,N-dimethyl-phenylalanine nitrile

sodium methylate

dimethyldibenzylammonium chloride

Downstream raw materials:

((S)-bibenzyl-α-yl)-dimethyl-amine

lefetamine