N-(3-(5-fluoro-2-(4-((1-methylpiperidin-4-yl)methoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

Base Information

Chemical Name:N-(3-(5-fluoro-2-(4-((1-methylpiperidin-4-yl)methoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide
CAS No.:1202756-99-7
Molecular Formula:C₂₆H₂₉FN₆O₂
Molecular Weight:476.554
Hs Code.:

Synonyms:N-(3-(5-fluoro-2-(4-((1-methylpiperidin-4-yl)methoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

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Chemical Property of N-(3-(5-fluoro-2-(4-((1-methylpiperidin-4-yl)methoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

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Technology Process of N-(3-(5-fluoro-2-(4-((1-methylpiperidin-4-yl)methoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

There total 3 articles about N-(3-(5-fluoro-2-(4-((1-methylpiperidin-4-yl)methoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1202759-93-0
C₂₃H₂₇FN₆O

: 814-68-6,25189-84-8
acryloyl chloride

: 1202756-99-7
N-(3-(5-fluoro-2-(4-((1-methylpiperidin-4-yl)methoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

Guidance literature:: C₂₃H₂₇FN₆O; acryloyl chloride; In tetrahydrofuran; at -10 ℃;

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 0.166667h;

Reference yield:

: 68621-88-5
(3-aminophenyl)carbamic acid tert-butyl ester

: 1202756-99-7
N-(3-(5-fluoro-2-(4-((1-methylpiperidin-4-yl)methoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Reflux

2.1: caesium carbonate; XPhos / palladium diacetate / 1,4-dioxane / Reflux; Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 20 °C

3.2: 0 °C

4.1: tetrahydrofuran / -10 °C

4.2: 0.17 h

With caesium carbonate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; XPhos; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;

Reference yield:

: 1202759-89-4
tert-butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)carbamate

: 1202756-99-7
N-(3-(5-fluoro-2-(4-((1-methylpiperidin-4-yl)methoxy)phenylamino)pyrimidin-4-ylamino)phenyl)acrylamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: caesium carbonate; XPhos / palladium diacetate / 1,4-dioxane / Reflux; Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 20 °C

2.2: 0 °C

3.1: tetrahydrofuran / -10 °C

3.2: 0.17 h

With caesium carbonate; trifluoroacetic acid; XPhos; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane;