[3-(2-CHLORO-5-FLUORO-PYRIMIDIN-4-YLAMINO)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER

Base Information

Chemical Name:[3-(2-CHLORO-5-FLUORO-PYRIMIDIN-4-YLAMINO)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER
CAS No.:1202759-89-4
Molecular Formula:C15H16ClFN4O2
Molecular Weight:338.769
Hs Code.:
Mol file:1202759-89-4.mol

Synonyms:tert-butyl 3-(2-chloro-5-fluoropyrimidin-4-ylamino)phenylcarbamate

Suppliers and Price of [3-(2-CHLORO-5-FLUORO-PYRIMIDIN-4-YLAMINO)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
tert-Butyl(3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)carbamate 97%
5g
$ 982.00

Crysdot
tert-Butyl(3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)carbamate 97%
1g
$ 327.00

Total 3 raw suppliers

Chemical Property of [3-(2-CHLORO-5-FLUORO-PYRIMIDIN-4-YLAMINO)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER

Chemical Property:

PSA：76.14000
LogP:4.50570

Purity/Quality:

98%min ^*data from raw suppliers

tert-Butyl(3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)carbamate 97% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [3-(2-CHLORO-5-FLUORO-PYRIMIDIN-4-YLAMINO)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER

There total 6 articles about [3-(2-CHLORO-5-FLUORO-PYRIMIDIN-4-YLAMINO)-PHENYL]-CARBAMIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 528882-16-8
(3-amino-phenyl)-methyl-carbamic acid tert-butyl ester

: 2927-71-1
2,4-dichloro-5-fluoropyrimidine

: 1202759-89-4
tert-butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)carbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; Reflux;

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1202759-89-4
tert-butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / tetrahydrofuran / 5 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

2.2: 2 h / 0 - 20 °C / Inert atmosphere

3.1: palladium on activated charcoal; hydrogen / methanol / 3 h / 20 °C / 3750.38 Torr / Autoclave

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Reflux

With dmap; palladium on activated charcoal; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

Reference yield:

: 99-09-2
3-nitro-aniline

: 1202759-89-4
tert-butyl (3-((2-chloro-5-fluoropyrimidin-4-yl)amino)phenyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dmap / tetrahydrofuran / 5 h / 0 - 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

2.2: 2 h / 0 - 20 °C / Inert atmosphere

3.1: palladium on activated charcoal; hydrogen / methanol / 3 h / 20 °C / 3750.38 Torr / Autoclave

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / Reflux

With dmap; palladium on activated charcoal; hydrogen; sodium hydride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;