[6-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl 4-nitrophenyl carbonate

Base Information

Chemical Name:[6-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl 4-nitrophenyl carbonate
CAS No.:144186-12-9
Molecular Formula:C₁₈H₁₉N₃O₇
Molecular Weight:389.365
Hs Code.:
DSSTox Substance ID:DTXSID601129710

Synonyms:SCHEMBL7310411;DTXSID601129710;[6-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl 4-nitrophenyl carbonate;144186-12-9

Suppliers and Price of [6-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl 4-nitrophenyl carbonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of [6-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl 4-nitrophenyl carbonate

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:8
Rotatable Bond Count:8
Exact Mass:389.12229995
Heavy Atom Count:28
Complexity:550

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)NC1=NC=C(C=C1)COC(=O)OC2=CC=C(C=C2)[N+](=O)[O-]

Technology Process of [6-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl 4-nitrophenyl carbonate

There total 5 articles about [6-[[(1,1-Dimethylethoxy)carbonyl]amino]-3-pyridinyl]methyl 4-nitrophenyl carbonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7693-46-1
4-Nitrophenyl chloroformate

: 169280-83-5
(5-hydroxymethylpyridin-2-yl)-carbamic acid t-butyl ester

: 144186-12-9
carbonic acid 6-tert-butoxycarbonylamino-pyridin-3-ylmethyl ester 4-nitro-phenyl ester

Guidance literature:: With 4-methyl-morpholine; In dichloromethane; at 0 ℃;
DOI:10.1021/jm970636+

Reference yield:

: 36052-24-1
methyl 6-aminonicotinoate

: 144186-12-9
carbonic acid 6-tert-butoxycarbonylamino-pyridin-3-ylmethyl ester 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / 4-(dimethylamino)pyridine / acetonitrile / 4 h / Ambient temperature

2: 1.064 g / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

3: 4-methylmorpholine / CH₂Cl₂ / 0 °C

With 4-methyl-morpholine; dmap; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm970636+

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 144186-12-9
carbonic acid 6-tert-butoxycarbonylamino-pyridin-3-ylmethyl ester 4-nitro-phenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / 4-(dimethylamino)pyridine / acetonitrile / 4 h / Ambient temperature

2: 1.064 g / LiAlH₄ / tetrahydrofuran / 1 h / 0 °C

3: 4-methylmorpholine / CH₂Cl₂ / 0 °C

With 4-methyl-morpholine; dmap; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane; acetonitrile;
DOI:10.1021/jm970636+